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DOI: 10.1055/s-0033-1343991
Management of Pediatric and Adolescent Breast Masses
Publikationsverlauf
Publikationsdatum:
23. Mai 2013 (online)
Abstract
Breast masses in children and adolescents are uncommon and most often benign. Occasionally, however, they require surgical intervention for lifestyle limiting symptoms or malignant potential. These masses are best evaluated with physical exam and ultrasound. Breast masses likely to be encountered by the surgeon in the pediatric and adolescent population include intraductal papillomas, phyllodes tumors, primary breast cancer, and metastatic lesions. Unlike adults, pediatric and adolescent breast cancer tends to be of the secretory variety and typically have less metastatic potential. However, cases of inflammatory and medullary breast cancers have also been reported in girls and appear more aggressive. Radiation exposure during breast development is a risk factor to subsequent development of breast cancer. Surgical objective for a concerning pediatric and adolescent breast mass is complete resection while preserving normal breast development, when appropriate. The need for routine axillary dissection for malignant cases in children appears unnecessary from the limited data available, and the authors favor sentinel lymph node sampling and reserve axillary dissection for positive lymph nodes.
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References
- 1 Neinstein LS, Atkinson J, Diament M. Prevalence and longitudinal study of breast masses in adolescents. J Adolesc Health 1993; 14 (4) 277-281
- 2 Simmons PS, Jayasinghe YL, Wold LE, Melton III LJ. Breast carcinoma in young women. Obstet Gynecol 2011; 118 (3) 529-536
- 3 Jayasinghe Y, Simmons PS. Breast disorders in the female. In: Fisher MM, Alderman EM, Kreipe RE, Rosenfeld WD, , eds. Textbook of Adolescent Health Care. Elk Grove Village, IL: American Academy of Pediatrics; 2011: 621-634
- 4 Bobo JK, Lee NC, Thames SF. Findings from 752,081 clinical breast examinations reported to a national screening program from 1995 through 1998. J Natl Cancer Inst 2000; 92 (12) 971-976
- 5 Pruthi S, Jones KN, Boughey JC, Simmons PS. Breast masses in adolescents: clinical pearls in the diagnostic evaluation. Am Fam Physician 2012; 86 (4) 325-326
- 6 Weinstein SP, Conant EF, Orel SG, Zuckerman JA, Bellah R. Spectrum of US findings in pediatric and adolescent patients with palpable breast masses. Radiographics 2000; 20 (6) 1613-1621
- 7 De Silva NK, Brandt ML. Disorders of the breast in children and adolescents, Part 2: breast masses. J Pediatr Adolesc Gynecol 2006; 19 (6) 415-418
- 8 Greydanus DE, Parks DS, Farrell EG. Breast disorders in children and adolescents. Pediatr Clin North Am 1989; 36 (3) 601-638
- 9 Fallat ME, Ignacio Jr RC. Breast disorders in children and adolescents. J Pediatr Adolesc Gynecol 2008; 21 (6) 311-316
- 10 Rosen PP. Papillary duct hyperplasia of the breast in children and young adults. Cancer 1985; 56 (7) 1611-1617
- 11 Wilson M, Cranor ML, Rosen PP. Papillary duct hyperplasia of the breast in children and young women. Mod Pathol 1993; 6 (5) 570-574
- 12 Parker SJ, Harries SA. Phyllodes tumours. Postgrad Med J 2001; 77 (909) 428-435
- 13 Alabassi A, Fentiman IS. Sarcomas of the breast. Int J Clin Pract 2003; 57 (10) 886-889
- 14 Chao TC, Lo YF, Chen SC, Chen MF. Sonographic features of phyllodes tumors of the breast. Ultrasound Obstet Gynecol 2002; 20 (1) 64-71
- 15 Chang DS, McGrath MH. Management of benign tumors of the adolescent breast. Plast Reconstr Surg 2007; 120 (1) 13e-19e
- 16 West KW, Rescorla FJ, Scherer III LR, Grosfeld JL. Diagnosis and treatment of symptomatic breast masses in the pediatric population. J Pediatr Surg 1995; 30 (2) 182-186 , discussion 186–187
- 17 Mangi AA, Smith BL, Gadd MA, Tanabe KK, Ott MJ, Souba WW. Surgical management of phyllodes tumors. Arch Surg 1999; 134 (5) 487-492 , discussion 492–493
- 18 Neinstein LS. Breast disease in adolescents and young women. Pediatr Clin North Am 1999; 46 (3) 607-629
- 19 Shannon C, Smith IE. Breast cancer in adolescents and young women. Eur J Cancer 2003; 39 (18) 2632-2642
- 20 Murphy JJ, Morzaria S, Gow KW, Magee JF. Breast cancer in a 6-year-old child. J Pediatr Surg 2000; 35 (5) 765-767
- 21 Ramirez G, Ansfield FJ. Carcinoma of the breast in children. Arch Surg 1968; 96 (2) 222-225
- 22 Nonomura A, Kimura A, Mizukami Y , et al. Secretory carcinoma of the breast associated with juvenile papillomatosis in a 12-year-old girl. A case report. Acta Cytol 1995; 39 (3) 569-576
- 23 Serour F, Gilad A, Kopolovic J, Krispin M. Secretory breast cancer in childhood and adolescence: report of a case and review of the literature. Med Pediatr Oncol 1992; 20 (4) 341-344
- 24 Eskelinen M, Vainio J, Tuominen L, Vihko R, Klemi P, Collan Y. Carcinoma of the breast in children. Z Kinderchir 1990; 45 (1) 52-55
- 25 Chamadol W, Pesie M, Puapairoj A. Inflammatory carcinoma of the breast in a 12-year-old Thai girl. J Med Assoc Thai 1987; 70 (9) 543-548
- 26 Ferguson Jr TB, McCarty Jr KS, Filston HC. Juvenile secretory carcinoma and juvenile papillomatosis: diagnosis and treatment. J Pediatr Surg 1987; 22 (7) 637-639
- 27 Karl SR, Ballantine TV, Zaino R. Juvenile secretory carcinoma of the breast. J Pediatr Surg 1985; 20 (4) 368-371
- 28 Rosen PP, Lyngholm B, Kinne DW, Beattie Jr EJ. Juvenile papillomatosis of the breast and family history of breast carcinoma. Cancer 1982; 49 (12) 2591-2595
- 29 Massé SR, Rioux A, Beauchesne C. Juvenile carcinoma of the breast. Hum Pathol 1981; 12 (11) 1044-1046
- 30 Rosen PP, Cantrell B, Mullen DL, DePalo A. Juvenile papillomatosis (Swiss cheese disease) of the breast. Am J Surg Pathol 1980; 4 (1) 3-12
- 31 Tavassoli FA, Norris HJ. Secretory carcinoma of the breast. Cancer 1980; 45 (9) 2404-2413
- 32 Heydenrych JJ, Villet WT, von der Heyden U. Carcinoma of the breast in children: a case report and review of the literature. S Afr Med J 1980; 57 (24) 1005-1008
- 33 Byrne MP, Fahey MM, Gooselaw JG. Breast cancer with axillary metastasis in an eight and one-half-year-old girl. Cancer 1973; 31 (3) 726-728
- 34 Oberman HA, Stephens PJ. Carcinoma of the breast in childhood. Cancer 1972; 30 (2) 470-474
- 35 Simpson JS, Barson AJ. Breast tumours in infants and children: a 40-year review of cases at a children's hospital. Can Med Assoc J 1969; 101 (2) 100-102
- 36 McDivitt RW, Stewart FW. Breast carcinoma in children. JAMA 1966; 195 (5) 388-390
- 37 Feig SA. Radiation risk from mammography: is it clinically significant?. AJR Am J Roentgenol 1984; 143 (3) 469-475
- 38 Guyer PB, Dewbury KC. Sonomammography in benign breast disease. Br J Radiol 1988; 61 (725) 374-378
- 39 Tanimura A, Konaka K. Carcinoma of the breast in a 5 years old girl. Acta Pathol Jpn 1980; 30 (1) 157-160
- 40 Nichini FM, Goldman L, Lapayowker MS, Levy WM, Maier W, Rosemond GP. Inflammatory carcinoma of the breast in a 12-year-old girl. Arch Surg 1972; 105 (3) 505-508
- 41 Lipitt WH, Medart Jr WS, Ramsey SN. Breast cancer in a 10-year-old girl. Surgery 1970; 68 (2) 395-396
- 42 Farrow JH, Ashikari H. Breast lesions in young girls. Surg Clin North Am 1969; 49 (2) 261-269
- 43 Close MB, Maximov NG. Carcinoma of the breast in young girls. Arch Surg 1965; 91: 386-389
- 44 Hammar B. Childhood breast carcinoma: report of a case. J Pediatr Surg 1981; 16 (1) 77-78
- 45 Teasdale C, Baum M. Breast cancer in a schoolgirl. Lancet 1976; 2 (7986) 627
- 46 Ashley S, Royle GT, Corder A , et al. Clinical, radiological and cytological diagnosis of breast cancer in young women. Br J Surg 1989; 76 (8) 835-837
- 47 Dehner LP, Hill DA, Deschryver K. Pathology of the breast in children, adolescents, and young adults. Semin Diagn Pathol 1999; 16 (3) 235-247
- 48 Rogers DA, Lobe TE, Rao BN , et al. Breast malignancy in children. J Pediatr Surg 1994; 29 (1) 48-51
- 49 Chateil JF, Arboucalot F, Pérel Y, Brun M, Boisserie-Lacroix M, Diard F. Breast metastases in adolescent girls: US findings. Pediatr Radiol 1998; 28 (11) 832-835
- 50 Gold DG, Neglia JP, Dusenbery KE. Second neoplasms after megavoltage radiation for pediatric tumors. Cancer 2003; 97 (10) 2588-2596
- 51 Saslow D, Boetes C, Burke W , et al; American Cancer Society Breast Cancer Advisory Group. American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography. CA Cancer J Clin 2007; 57 (2) 75-89