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Synthesis 2014; 46(15): 2051-2056
DOI: 10.1055/s-0033-1341265
DOI: 10.1055/s-0033-1341265
paper
Synthesis of Dihydropyrrole Derivatives by a Palladium-Catalyzed Heck and Suzuki Cross-Coupling Cascade Reaction
Weitere Informationen
Publikationsverlauf
Received: 16. Januar 2014
Accepted after revision: 31. März 2014
Publikationsdatum:
13. Mai 2014 (online)
Abstract
An expedient protocol for the synthesis of 5-aryl-2,3-dihydropyrroles, starting from N-tosyl-protected 2-methylprop-2-en-1-amine, alkynyl bromides, and arylboronic acids, is described. The sequential reaction sequence involves nucleophilic addition of the sulfonamide to the alkynyl bromide, followed by a palladium-catalyzed tandem intramolecular Heck and intermolecular Suzuki cross-coupling reaction of the bromoalkene adduct.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
- Supporting Information
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