Synthesis 2014; 46(16): 2201-2219
DOI: 10.1055/s-0033-1341233
paper
© Georg Thieme Verlag Stuttgart · New York

Guanidinium Ylide Mediated Aziridination from Arylaldehydes: Scope and Limitations in the Formation of Unactivated 3-Arylaziridine-2-carboxylates

Yukiko Oda
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Kihito Hada
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Marie Miyata
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Chisato Takahata
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Yukiko Hayashi
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Masato Takahashi
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Naoki Yajima
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Makiko Fujinami
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
,
Tsutomu Ishikawa*
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260-8675, Japan   Fax: +81(43)2262944   Email: benti@faculty.chiba-u.jp
› Author Affiliations
Further Information

Publication History

Received: 28 February 2014

Accepted after revision: 23 March 2014

Publication Date:
12 May 2014 (online)


Abstract

The scope and limitations of guanidinium ylide mediated aziridinations from arylaldehydes yielding unactivated 3-arylaziridine-2-carboxylates, applicable to asymmetric synthesis, are discussed.

Supporting Information

 
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