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Synthesis 2014; 46(10): 1362-1366
DOI: 10.1055/s-0033-1341102
DOI: 10.1055/s-0033-1341102
special topic
A Facile Route to H-Pyrazolo[5,1-a]isoquinolines through a Multicomponent Reaction of 2-Alkynylbenzaldehyde, Sulfonylhydrazine, and Benzyne
Weitere Informationen
Publikationsverlauf
Received: 09. Februar 2014
Accepted after revision: 13. März 2014
Publikationsdatum:
28. März 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201410/lookinside/thumbnails/10.1055-s-0033-1341102-1.jpg)
Abstract
A facile and efficient route for the generation of H-pyrazolo[5,1-a]isoquinolines via a silver triflate catalyzed three-component reaction of 2-alkynylbenzaldehyde, tosylhydrazine, and benzyne is reported. This reaction proceeds smoothly under mild conditions with high efficiency.
Key words
2-alkynylbenzaldehyde - benzyne - H-pyrazolo[5,1-a]isoquinoline - silver triflate - tosylhydrazineSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. Included are experimental procedure, characterization data, and 1H and 13C NMR spectra of compounds 3.
- Supporting Information
-
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