Synlett 2014; 25(09): 1191-1196
DOI: 10.1055/s-0033-1340738
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© Georg Thieme Verlag Stuttgart · New York

Organic Photoredox Catalysis as a General Strategy for Anti-Markovnikov Alkene Hydrofunctionalization

David A. Nicewicz*
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA   Fax: +1(919)9622388   Email: nicewicz@unc.edu
,
David S. Hamilton
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA   Fax: +1(919)9622388   Email: nicewicz@unc.edu
› Author Affiliations
Further Information

Publication History

Received: 02 December 2013

Accepted after revision: 13 January 2014

Publication Date:
05 March 2014 (online)


Abstract

The development of a general catalyst system for the ­direct anti-Markovnikov hydrofunctionalization of alkenes is pres­ented. A unique catalyst system comprised of an acridinium photooxidant and a hydrogen atom transfer reagent allows for a range of alkene anti-Markovnikov hydrofunctionalization reactions including hydroalkoxylation, hydroamination, and hydroacetoxylation.

 
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