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Synlett 2014; 25(07): 905-910
DOI: 10.1055/s-0033-1340621
DOI: 10.1055/s-0033-1340621
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Metal-Free-Catalyzed Intramolecular Carbocyanation of Activated Alkenes: New Entry To Access Functionalized Nitriles Containing Quaternary Carbon Centers
Weitere Informationen
Publikationsverlauf
Received: 17. November 2013
Accepted after revision: 12. Dezember 2013
Publikationsdatum:
05. Februar 2014 (online)
![](https://www.thieme-connect.de/media/synlett/201407/lookinside/thumbnails/10.1055-s-0033-1340621-1.jpg)
Abstract
Intramolecular carbocyanation reaction of alkenes has emerged as a powerful tool for preparing functionalized nitriles. In contrast to transition-metal-catalyzed processes, we have recently developed a metal-free carbocyanation (alkenylcyanation and acylcyanation) approach to construct functionalized nitriles incorporating a quaternary carbon center. This article summarizes our recent exploratory studies in this field.
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For reviews and highlights on metal-involved carbocyanation, see:
For intermolecualr carbocyanation of alkenes, see:
For selected recent examples for other cyanofunctionalizations, see:
For metal-involved intramolecualr carbocyanation of alkenes, see:
Selected recent reviews on the construction of quaternary carbon centers, see:
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For examples of Lewis base catalyzed acylcyanation of imines, see:
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