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Synthesis 2014; 46(06): 781-786
DOI: 10.1055/s-0033-1340616
DOI: 10.1055/s-0033-1340616
paper
An Improved Protocol for the Preparation of 5-Substituted Tetrazoles from Organic Thiocyanates and Nitriles
Further Information
Publication History
Received: 01 November 2013
Accepted after revision: 19 December 2013
Publication Date:
21 January 2014 (online)
Abstract
Organic thiocyanates and nitriles are converted efficiently into the corresponding 5-substituted 1H-tetrazoles by treatment with zinc(II) chloride and sodium azide in aliphatic alcohols. The presented procedure provides mild reaction conditions, short reaction times, and good to excellent yields for a wide range of substrates, including deactivated aliphatic nitriles and thermally unstable thiocyanates.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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