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Synlett 2014; 25(4): 509-514
DOI: 10.1055/s-0033-1340551
DOI: 10.1055/s-0033-1340551
letter
Studies on the Phthalidation of Heteroarenes: A Facile Preparation of 3-(Heteroaryl)phthalides via Triflic Acid Mediated Phthalidation
Further Information
Publication History
Received: 19 October 2013
Accepted after revision: 09 December 2013
Publication Date:
31 January 2014 (online)
Abstract
A triflic acid mediated heteroarylation of phthalaldehydic acid in 1,2-dichloroethane at reflux temperature leads to the formation of 3-heteroarylphthalides. This method for the phthalidation of heteroarenes can be utilized for the successful preparation of mono-, bis- and tris-heteroarylphthalides.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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References and Notes
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For syntheses of benzo[c]thiophenes, see ref. 7 and:
For applications of benzo[c]thiophenes, see: