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Synlett 2014; 25(1): 75-80
DOI: 10.1055/s-0033-1340250
DOI: 10.1055/s-0033-1340250
letter
Application of 3-Bromo-3-ethylazetidines and 3-Ethylideneazetidines for the Synthesis of Functionalized Azetidines
Further Information
Publication History
Received: 14 August 2013
Accepted after revision: 14 October 2013
Publication Date:
04 December 2013 (online)
Abstract
The synthetic utility of 3-bromo-3-ethylazetidines has been demonstrated by the straightforward preparation of 3-alkoxy-, 3-aryloxy-, 3-acetoxy-, 3-hydroxy-, 3-cyano-, 3-carbamoyl- and 3-amino-3-ethylazetidines. In addition, 3-bromo-3-ethylazetidines have been successfully deployed as precursors for a convenient synthesis of 3-ethylideneazetidines, which served as starting materials for the preparation of novel functionalized azetidines and spirocyclic azetidine building blocks.
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References and Notes
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