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Synlett 2014; 25(1): 155-156
DOI: 10.1055/s-0033-1340156
DOI: 10.1055/s-0033-1340156
spotlight
5-Alkyl and 5,5-Dialkyl Meldrum’s Acids
Further Information
Publication History
Publication Date:
21 November 2013 (online)
Introduction
5-Alkyl and 5,5-dialkyl Meldrum’s acids (1 and 2, respectively) are used in total synthesis.[1] Monoalkylated derivatives 1 are synthesized from Meldrum’s acid 3 by condensation with aldehyde[2] (or by acylation[3]) followed by hydrogenation.
5,5-Dialkyl Meldrum’s acids 2 can be obtained by alkylation of Meldrum’s acid 3 or its monoalkylated derivatives 1 (Scheme [1]).[4] Herein, reactions of Meldrum’s acids 1 and 2 proceeding with destruction of 1,3-dioxane cycle are reviewed.
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References
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