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Synlett 2014; 25(1): 153-154
DOI: 10.1055/s-0033-1340155
DOI: 10.1055/s-0033-1340155
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Acetaldehyde: Use in Organocatalysis
Further Information
Publication History
Publication Date:
19 November 2013 (online)
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Introduction
Acetaldehyde is a small organic molecule and the simplest enolazable aldehyde. It is an important synthon for the construction of β-amino acid derivatives, α-hydroxy ketones, and so forth, if suitable reagents are employed. Despite this versatility, the use of acetaldehyde can be complicated due to its tendency to oligomerize or polymerize.
Recently, several research groups reported the multifarious utility of acetaldehyde in many diverse asymmetric organocatalytic transformations by controlling the reactivity of acetaldehyde.[1] The reactions furnished the corresponding products in high yields with stereoselectivities. An overview of typical applications of acetaldehyde is shown in Scheme [1].
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