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Synthesis 2013; 45(23): 3245-3250
DOI: 10.1055/s-0033-1339918
DOI: 10.1055/s-0033-1339918
paper
Palladium-Catalyzed Cyanation of Quinazoline-4-tosylates for Access to 4-CN-Functionalized Quinazolines
Further Information
Publication History
Received: 28 July 2013
Accepted after revision: 16 September 2013
Publication Date:
14 October 2013 (online)
Abstract
A highly efficient palladium-catalyzed cyanation of quinazoline-4-tosylates is disclosed. The method is successfully developed for the direct access to various 4-CN-functionalized quinazolines, which are potentially useful as biologically and pharmaceutically active compounds. The reactions were performed under mild conditions using inexpensive copper(I) cyanide as cyano source in good to excellent yields and great functional group diversities.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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