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Synlett 2013; 24(17): 2233-2240
DOI: 10.1055/s-0033-1339858
DOI: 10.1055/s-0033-1339858
letter
DMAP-Catalyzed Regel-Type Direct C-2 (Hetero)Aroylation of Oxazoles and Thiazoles Derivatives with Acid Chlorides
Further Information
Publication History
Received: 18 July 2013
Accepted after revision: 27 August 2013
Publication Date:
23 September 2013 (online)
Abstract
A Regel-type transition-metal-free direct C-2 aroylation of (benzo)oxazoles, (benzo)thiazoles and 1,3,4-oxadiazoles with acid chlorides catalyzed by N,N-dimethyl-4-aminopyridine (DMAP) is described. This methodology is effective with several aroyl and heteroaroyl chlorides affording the corresponding 2-ketoazoles in moderate to excellent yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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