Regioselective Palladium(II)-Catalyzed Desulfitative Heck-Type Reaction: Access to α-Benzyl-β-keto Esters from Baylis–Hillman Adducts and Sodium Sulfinates

Abstract

A new palladium(II)-catalyzed desulfitative Heck-Type arylation from sodium arenesulfinates and Baylis–Hillman adducts for the synthesis of highly functionalized α-benzyl-β-keto ester derivatives in good to excellent yields has been developed. This methodology is simple and mild, it can utilize halogen bearing building blocks, and it has excellent regioselectivity.

Key words

Heck reaction - Baylis–Hillman adducts - palladium - desulfitative - α-benzyl-β-keto esters

• References

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