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Synthesis 2013; 45(17): 2438-2446
DOI: 10.1055/s-0033-1339350
DOI: 10.1055/s-0033-1339350
paper
Reactivity of the Pyrimidine Nitrogen Atom toward an Acetal Moiety: Formation of 3-Ethoxy-2,3-dihydroimidazo[1,2-c]pyrimidines by Intramolecular Cyclization of N-(2,2-Diethoxyethyl)pyrimidine-4-amines
Further Information
Publication History
Received: 03 April 2013
Accepted after revision: 13 June 2013
Publication Date:
22 July 2013 (online)
Abstract
A new protocol was developed for the synthesis of 2,3-dihydroimidazo[1,2-c]pyrimidines, based on an intramolecular reaction between a pyrimidine nitrogen atom and an acetal moiety in the presence of boron trifluoride etherate. The method was expanded to permit the synthesis of the triheterocyclic imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine system.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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