Synthesis 2013; 45(17): 2447-2457
DOI: 10.1055/s-0033-1339348
paper
© Georg Thieme Verlag Stuttgart · New York

The Preparation of Various New Heterocyclic Compounds via Cyclization of Substituted Derivatives of Phenacyl Esters of Hydrazonoacetic Acid

Authors

  • Radek Mělnický

    b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
  • Martin Grepl

    b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
  • Antonín Lyčka

    c   Research Institute for Organic Syntheses, Rybitvi 296, 533 54 Pardubice, Czech Republic
    d   University of Hradec Kralove, Faculty of Science, Rokitanského 62, 500 03 Hradec Králove 3, Czech Republic
  • Valerio Bertolasi

    e   Dipartimento di Chimica and Centro di Structturistica Diffrattometrica, University of Ferrara, Via L. Borsari 46, 441 00 Ferrara, Italy
  • Lubomír Kvapil

    b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
  • Barbora Dvořáková

    b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
  • Pavel Hradil*

    a   Department of Organic Chemistry, Palacky University, Tr. 17. Listopadu 12, 771 46 Olomouc, Czech Republic
    b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
Further Information

Publication History

Received: 12 March 2013

Accepted after revision: 10 June 2013

Publication Date:
01 August 2013 (online)


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Abstract

A procedure for the preparation of derivatives of phen­acyl hydrazonopropanoates and their application in the synthesis of various heterocycles has been developed. Not only is the preparation of indole derivatives described, but also a new method for the preparation of previously unknown pyridazine derivatives.

Supporting Information