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Synlett 2013; 24(14): 1809-1812
DOI: 10.1055/s-0033-1339337
DOI: 10.1055/s-0033-1339337
letter
Gold-Catalyzed Intermolecular Oxidation of Terminal Alkynes: Simple and Efficient Synthesis of α-Mesyloxy Ketones
Further Information
Publication History
Received: 21 April 2013
Accepted after revision: 10 June 2013
Publication Date:
01 August 2013 (online)
Abstract
A variety of terminal alkynes were efficiently converted into the corresponding α-mesyloxy ketones through gold-catalyzed intermolecular oxidation in the presence of 3,5-dichloropyridine N-oxide as the oxidant. The reaction is proposed to proceed via α-oxo gold carbene intermolecular O–H insertion.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
-
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For some gold-catalyzed oxidative reactions, the possible alkenyl gold mechanism was also proposed, see: