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Synlett 2013; 24(12): 1464-1470
DOI: 10.1055/s-0033-1338879
DOI: 10.1055/s-0033-1338879
synpacts
Using Chemical Knowledge to Uncover New Biological Function: Discovery of the Cylindrocyclophane Biosynthetic Pathway
Further Information
Publication History
Received: 28 March 2013
Accepted: 02 May 2013
Publication Date:
14 June 2013 (online)
Abstract
An understanding of organic chemistry can play a central role in uncovering enzymes with new biochemical functions. We have recently identified the enzymes involved in the biosynthesis of the cylindrocyclophanes, a structurally unique family of natural products, and found that this pathway employs a remarkable macrocyclization event that requires functionalization of an unactivated carbon atom. This work illustrates the potential of using chemically guided approaches for enzyme discovery.
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