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Synthesis 2013; 45(13): 1853-1856
DOI: 10.1055/s-0033-1338878
DOI: 10.1055/s-0033-1338878
paper
Synthesis and Characterization of Ferrocene Acetals and Evaluation of Their Antineoplastic Properties by Using Breast Cancer Cell Lines In Vitro
Further Information
Publication History
Received: 24 April 2013
Accepted: 08 May 2013
Publication Date:
05 June 2013 (online)
To Dr. Scott E. Denmark in his 60th birthday’s celebration. With gratitude and best wishes from Dr. Mirna Rivera Claudio.
Abstract
Two new ferrocene acetals were synthesized from a chiral diol in toluene and characterized by a range of spectroscopic techniques. The biological activities of the products were evaluated by using the breast adenocarcinoma cell lines T47D, MCF7, ZR-75-1, MD-MB-468, and MD-MB-231. In comparison with tamoxifen, the ferrocene acetals showed moderate anticancer activity in vitro for the T47D and MCF7 cell lines.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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