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Synthesis 2014; 46(10): 1334-1338
DOI: 10.1055/s-0033-1338612
DOI: 10.1055/s-0033-1338612
special topic
Synergistic Iron-and-Amine Catalysis in Carbocyclizations
Weitere Informationen
Publikationsverlauf
Received: 08. Januar 2014
Accepted after revision: 25. Februar 2014
Publikationsdatum:
19. März 2014 (online)
![](https://www.thieme-connect.de/media/synthesis/201410/lookinside/thumbnails/10.1055-s-0033-1338612-1.jpg)
Dedicated to Professor Max Malacria on the occasion of his 65th birthday
Abstract
The fruitful merger of iron catalysis to amine catalysis was successfully applied in the direct intramolecular addition of aldehydes to non-activated alkynes. Accordingly, the carbocyclizations of a range of formyl-alkynes afforded the corresponding cyclopentanes in good to excellent yields. Experimental evidence tends to support a synergistic enamine/π-activation reaction mechanism.
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