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Synthesis 2014; 46(04): 522-530
DOI: 10.1055/s-0033-1338574
DOI: 10.1055/s-0033-1338574
paper
Anilines as Substrates in Consecutive Four-Component Synthesis of Novel 1-Aryl-5-benzoyl-6-phenyl-3,4-dihydropyridin-2(1H)-ones
Further Information
Publication History
Received: 04 October 2013
Accepted after revision: 18 November 2013
Publication Date:
10 December 2013 (online)
Dedicated to Prof. Dr. Klaus Theodor Wanner on the occasion of his 60th birthday
Abstract
The consecutive four-component synthesis of 5-acylpyridin-2(1H)-ones initiated by a copper-free alkynylation in a one-pot fashion has been expanded to include considerably less nucleophilic anilines as the amine component in the Michael addition step by altering the solvent system to 1,4-dioxane; 17 examples for the synthesis of 1-aryl-5-benzoyl-6-phenyl-3,4-dihydropyridin-2(1H)-ones were obtained in moderate to good yields.
Supporting Information
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