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Synthesis 2014; 46(03): 313-319
DOI: 10.1055/s-0033-1338560
DOI: 10.1055/s-0033-1338560
paper
Synthesis of 3-Trifluoromethylbenzofurans via Palladium-Catalyzed Tandem Elimination/Annulation of β-Chloro-β-(trifluoromethyl)styrenes with 2-Halophenols
Further Information
Publication History
Received: 14 September 2013
Accepted after revision: 25 October 2013
Publication Date:
21 November 2013 (online)
Abstract
A palladium-catalyzed tandem elimination and annulation reaction has been developed. In this way, a variety of 3-trifluoromethybenzofurans were prepared in moderate to good yields via tandem reaction of β-chloro-β-(trifluoromethyl)styrenes with 2-iodophenols and 2-bromophenols.
Key words
tandem reaction - trifluoromethyl - benzofuran - X-phos - palladium acetate - cesium carbonateSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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