Synthesis of Water-Soluble Vinyl Selenides and Their High Glutathione Peroxidase (GPx)-Like Antioxidant Activity

Abstract

A convenient procedure for the synthesis of novel bis-(1-hydroxymethyl-2-halo-3-hydroxy-1-propylene) selenides has been developed. On oxidation these compounds form novel seleno-spiro compounds and their glutathione peroxidase mimetic activity has been studied. They promote the hydrogen peroxide oxidation of phenylmethanethiol to the corresponding disulfide via a catalytic cycle.

Key words

alkynes - selenium - oxidation - spiro compounds - diols

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