Ultraschall Med 2013; 34(3): 238-253
DOI: 10.1055/s-0033-1335375
Guideline
© Georg Thieme Verlag KG Stuttgart · New York

EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography.Part 2: Clinical Applications

D. Cosgrove
1   Div. of Radiology, Imperial and Kings Colleges, London, UK
,
F. Piscaglia
2   Div. Internal Medicine, University of Bologna, Bologna Italy
,
J. Bamber
3   The Joint Department of Physics, Division of Radiotherapy and Imaging, Institute of Cancer Research and Royal Marsden Hospital, NHS Foundation Trust, London, United Kingdom
,
J. Bojunga
4   Department of Internal Medicine I, Endocrinology and Diabetology, Goethe-University, Frankfurt, Germany
,
J.-M. Correas
5   Adult Radiology, Paris Descartes University & Necker University Hospital, France, Institut Langevin – Ondes et Images ESPCI Paris Tech, CNRS UMR 7587 INSERM U 979
,
O. H. Gilja
6   National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway and Department of Clinical Medicine, University of Bergen, Norway
,
A. S. Klauser
7   Department of Radiology, Innsbruck Medical University, Austria
,
I. Sporea
8   Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Victor Babeş” Timişoara, Romania
,
F. Calliada
9   Div. of Radiology, University of Pavia, Policlinico San Matteo, Italy
,
V. Cantisani
10   Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, Univ. Sapienza, Rome, Italy
,
M. D’Onofrio
11   Department of Radiology, GB Rossi University Hospital, University of Verona, Italy
,
E. E. Drakonaki
12   Div. of Radiology, University Hospital Heraklion, Crete, Greece
,
M. Fink
13   Ecole Supérieure de Physique et de Chimie de la Ville de Paris, France
,
M. Friedrich-Rust
14   Department of Internal Medicine I, Gastroenterology and Hepatology, Goethe-University, Frankfurt, Germany
,
J. Fromageau
3   The Joint Department of Physics, Division of Radiotherapy and Imaging, Institute of Cancer Research and Royal Marsden Hospital, NHS Foundation Trust, London, United Kingdom
,
R. F. Havre
15   National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway
,
C. Jenssen
16   Div. Gastroenterology, Department of Internal Medicine, Krankenhaus Märkisch Oderland, Strausberg, Germany
,
R. Ohlinger
17   Department of Obstetrics and Gynecology, Breast unit, University Greifswald, Germany
,
A. Săftoiu
18   Department of Gastroenterology, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania
,
F. Schaefer
19   Unit of Breast Imaging and Interventions, University Hospital Schleswig-Holsten Campus Kiel, Germany
,
C. F. Dietrich
20   Div. Gastroenterology & Oncology, Caritas Krankenhaus, Bad Mergentheim, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
19 April 2013 (online)

Abstract

The clinical part of these Guidelines and Recommendations produced under the auspices of the European Federation of Societies for Ultrasound in Medicine and Biology EFSUMB assesses the clinically used applications of all forms of elastography, stressing the evidence from meta-analyses and giving practical advice for their uses and interpretation. Diffuse liver disease forms the largest section, reflecting the wide experience with transient and shear wave elastography . Then follow the breast, thyroid, gastro-intestinal tract, endoscopic elastography, the prostate and the musculo-skeletal system using strain and shear wave elastography as appropriate. The document is intended to form a reference and to guide clinical users in a practical way.

Zusammenfassung

Der klinische Teil dieser unter der Schirmherrschaft der EFSUMB erstellten Richtlinien und Empfehlungen beurteilt die klinisch genutzten Anwendungen aller Formen der Elastografie, betont die Evidenz von Meta-Analysen und gibt praktische Hinweise in Bezug auf Einsatz und Interpretation der Elastografie. Die diffusen Lebererkrankungen nehmen den größten Teil ein und spiegeln somit die umfangreiche Erfahrung in der transienten und der ShearWave-Elastografie wider. Es folgen Brust, Schilddrüse, Gastrointestinaltrakt, endoskopische Elastografie, Prostata und Muskel-Skelett-System unter Verwendung von Strain und gegebenenfalls ShearWave-Elastografie. Diese Publikation soll als Empfehlung dienen und klinische Anwender auf praktische Art anleiten.

 
  • References

  • 1 Bamber J, Cosgrove D, Dietrich CF et al. EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology. Ultraschall in Med 2013; 34: 169-184
  • 2 Claudon M, Dietrich CF, Choi BI et al Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver-update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultraschall in Med 2013; 34: 11-29
  • 3 Castera L, Foucher J, Bernard PH et al. Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations. Hepatology 2010; 51: 828-835
  • 4 Gebo KA, Herlong HF, Torbenson MS et al. Role of liver biopsy in management of chronic hepatitis C: a systematic review. Hepatology 2002; 36: S161-172
  • 5 Seeff LB, Everson GT, Morgan TR et al. Complication rate of percutaneous liver biopsies among persons with advanced chronic liver disease in the HALT-C trial. Clin Gastroenterol Hepatol 2010; 8: 877-883
  • 6 Stotland BR, Lichtenstein GR. Liver biopsy complications and routine ultrasound. Am J Gastroenterol 1996; 91: 1295-1296
  • 7 Regev A, Berho M, Jeffers LJ et al. Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol 2002; 97: 2614-2618
  • 8 Goertz RS, Egger C, Neurath MF et al. Impact of Food Intake, Ultrasound Transducer, Breathing Maneuvers and Body Position on Acoustic Radiation Force Impulse (ARFI) Elastometry of the Liver. Ultraschall in Med 2012; 33: 380-385
  • 9 Millonig G, Friedrich S, Adolf S et al. Liver stiffness is directly influenced by central venous pressure. J Hepatol 2010; 52: 206-210
  • 10 Sagir A, Erhardt A, Schmitt M et al. Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage. Hepatology 2008; 47: 592-595
  • 11 Mederacke I, Wursthorn K, Kirschner J et al. Food intake increases liver stiffness in patients with chronic or resolved hepatitis C virus infection. Liver Int 2009; 29: 1500-1506
  • 12 Millonig G, Reimann FM, Friedrich S et al. Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis. Hepatology 2008; 48: 1718-1723
  • 13 Reiberger T, Ferlitsch A, Payer BA et al. Non-selective beta-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis. J Gastroenterol 2011; 47: 561-568
  • 14 Karlas T, Pfrepper C, Wiegand J et al. Acoustic radiation force impulse imaging (ARFI) for non-invasive detection of liver fibrosis: examination standards and evaluation of interlobe differences in healthy subjects and chronic liver disease. Scand J Gastroenterol 2011; 46: 1458-1467
  • 15 Piscaglia F, Salvatore V, Di Donato R et al. Accuracy of VirtualTouch Acoustic Radiation Force Impulse (ARFI) imaging for the diagnosis of cirrhosis during liver ultrasonography. Ultraschall in Med 2011; 32: 167-175
  • 16 D'Onofrio M, Gallotti A, Mucelli RP. Tissue quantification with acoustic radiation force impulse imaging: Measurement repeatability and normal values in the healthy liver. Am J Roentgenol Am J Roentgenol 2010; 195: 132-136
  • 17 Talwalkar JA, Kurtz DM, Schoenleber SJ et al. Ultrasound-based transient elastography for the detection of hepatic fibrosis: systematic review and meta-analysis. Clin Gastroenterol Hepatol 2007; 5: 1214-1220
  • 18 Friedrich-Rust M, Ong MF, Martens S et al. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 2008; 134: 960-974
  • 19 Tsochatzis EA, Gurusamy KS, Ntaoula S et al. Elastography for the diagnosis of severity of fibrosis in chronic liver disease: a meta-analysis of diagnostic accuracy. J Hepatol 2007; 54: 650-659
  • 20 EASL. EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. J Hepatology 2011; 55: 245-264
  • 21 Chan HL, Wong GL, Choi PC et al. Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B. J Viral Hepat 2009; 16: 36-44
  • 22 Chon YE, Choi EH, Song KJ et al. Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis. PLoS One 2012; 7: e44930
  • 23 Wong VW, Vergniol J, Wong GL et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 2010; 51: 454-462
  • 24 de Ledinghen V, Wong VW, Vergniol J et al. Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan(R). J Hepatol 2012; 56: 833-839
  • 25 Friedrich-Rust M, Hadji-Hosseini H, Kriener S et al. Transient elastography with a new probe for obese patients for non-invasive staging of non-alcoholic steatohepatitis. Eur Radiol 2010; 20: 2390-2396
  • 26 Myers RP, Pomier-Layrargues G, Kirsch R et al. Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients. Hepatology 2012; 55: 199-208
  • 27 de Ledinghen V, Vergniol J, Foucher J et al. Feasibility of liver transient elastography with FibroScan using a new probe for obese patients. Liver Int 2010; 30: 1043-1048
  • 28 Adebajo CO, Talwalkar JA, Poterucha JJ et al. Ultrasound-based transient elastography for the detection of hepatic fibrosis in patients with recurrent hepatitis C virus after liver transplantation: a systematic review and meta-analysis. Liver Transpl 2012; 18: 323-331
  • 29 Vizzutti F, Arena U, Romanelli RG et al. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology 2007; 45: 1290-1297
  • 30 Bureau C, Metivier S, Peron JM et al. Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease. Aliment Pharmacol Ther 2008; 27: 1261-1268
  • 31 Castera L, Le Bail B, Roudot-Thoraval F et al. Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores. J Hepatol 2009; 50: 59-68
  • 32 Sporea I, Ratiu I, Sirli R et al. Value of transient elastography for the prediction of variceal bleeding. World J Gastroenterol 2011; 17: 2206-2210
  • 33 Pritchett S, Cardenas A, Manning D et al. The optimal cut-off for predicting large oesophageal varices using transient elastography is disease specific. J Viral Hepat 2011; 18: e75-80
  • 34 Colecchia A, Montrone L, Scaioli E et al. Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis. Gastroenterology 2012; 143: 646-654
  • 35 Berzigotti A, Piscaglia F. Ultrasound in portal hypertension--part 1. Ultraschall in Med 2011; 32: 548-568
  • 36 Vergniol J, Foucher J, Terrebonne E et al. Noninvasive tests for fibrosis and liver stiffness predict 5-year outcomes of patients with chronic hepatitis C. Gastroenterology 2011; 140: 1970-1979
  • 37 Masuzaki R, Tateishi R, Yoshida H et al. Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography. Hepatology 2009; 49: 1954-1961
  • 38 Jung KS, Kim SU, Ahn SH et al. Risk assessment of hepatitis B virus-related hepatocellular carcinoma development using liver stiffness measurement (FibroScan). Hepatology 2011; 53: 885-894
  • 39 Roulot D, Costes JL, Buyck JF et al. Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years. Gut 2011; 60: 977-984
  • 40 Fraquelli M, Rigamonti C, Casazza G et al. Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 2007; 56: 968-973
  • 41 Bonino F, Arena U, Brunetto MR et al. Liver stiffness, a non-invasive marker of liver disease: a core study group report. Antivir Ther 2010; 15: 69-78
  • 42 Friedrich-Rust M, Wunder K, Kriener S et al. Liver fibrosis in viral hepatitis: noninvasive assessment with acoustic radiation force impulse imaging versus transient elastography. Radiology 2009; 252: 595-604
  • 43 Sporea I, Sirli R, Bota S et al. Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis?. World J Radiol 2011; 3: 188-193
  • 44 Sporea I, Bota S, Peck-Radosavljevic M et al. Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study. Eur J Radiol 2012; 81: 4112-4118
  • 45 Rizzo L, Calvaruso V, Cacopardo B et al. Comparison of transient elastography and acoustic radiation force impulse for non-invasive staging of liver fibrosis in patients with chronic hepatitis C. Am J Gastroenterol 2011; 106: 2112-2120
  • 46 Sporea I, Bota S, Sirli R et al. The value of ARFI elastography for fibrosis evaluation in patients with chronic hepatitis C in comparison with liver biopsy – an international multicenter study. In, The International Liver Congress. Barcelona, Spani J Hepatol 2012; S420-S421
  • 47 Yoneda M, Suzuki K, Kato S et al. Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse elastography. Radiology 2010; 256: 640-647
  • 48 Friedrich-Rust M, Romen D, Vermehren J et al. Acoustic radiation force impulse-imaging and transient elastography for non-invasive assessment of liver fibrosis and steatosis in NAFLD. Eur J Radiol 2012; 81: e325-331
  • 49 Crespo G, Fernandez-Varo G, Marino Z et al. ARFI, FibroScan(R), ELF, and their combinations in the assessment of liver fibrosis: A prospective study. J Hepatol 2012; 57: 281-287
  • 50 Friedrich-Rust M, Nierhoff J, Lupsor M et al. Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis. J Viral Hepat 2012; 19: e212-219
  • 51 Toshima T, Shirabe K, Takeishi K et al. New method for assessing liver fibrosis based on acoustic radiation force impulse: a special reference to the difference between right and left liver. J Gastroenterol 2011; 46: 705-711
  • 52 Bavu E, Gennisson JL, Couade M et al. Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients. Ultrasound Med Biol 2011; 37: 1361-1373
  • 53 Ferraioli G, Tinelli C, Dal BelloB et al. Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: A pilot study. Hepatology 2012; 56: 2125-2133
  • 54 Ferraioli G, Tinelli C, Zicchetti M et al. Reproducibility of real-time shear wave elastography in the evaluation of liver elasticity. Eur J Radiol 2012; 81: 3102-3106
  • 55 Yoon KT, Lim SM, Park JY et al. Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation. Dig Dis Sci 2012; 57: 1682-1691
  • 56 Bota S, Sporea I, Peck-Radosavljevic M et al. The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: A retrospective multicentre study. Dig Liver Dis 2013; DOI: doi.org/10.1016/j.dld.2013.1002.1008.
  • 57 Bota S, Sporea I, Sirli R et al. Factors that influence the correlation of acoustic radiation force impulse (ARFI), elastography with liver fibrosis. Med Ultrason 2011; 13: 135-140
  • 58 Friedrich-Rust M, Ong MF, Herrmann E et al. Real-time elastography for noninvasive assessment of liver fibrosis in chronic viral hepatitis. Am J Roentgenol Am J Roentgenol 2007; 188: 758-764
  • 59 Tatsumi C, Kudo M, Ueshima K et al. Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan) and real-time tissue elastography. Intervirology 2008; 51: 27-33
  • 60 Fujimoto K, Kato M, Kudo M et al. Novel image analysis method using ultrasound elastography for noninvasive evaluation of hepatic fibrosis in patients with chronic hepatitis C. Oncology 2013; 84: 3-12
  • 61 Ying L, Lin X, Xie ZL et al. Clinical utility of acoustic radiation force impulse imaging for identification of malignant liver lesions: a meta-analysis. Eur Radiol 2012; 22: 2798-2805
  • 62 Yu H, Wilson SR. Differentiation of benign from malignant liver masses with Acoustic Radiation Force Impulse technique. Ultrasound Q 2011; 27: 217-223
  • 63 Onur MR, Poyraz AK, Ucak EE et al. Semiquantitative strain elastography of liver masses. J Ultrasound Med 2012; 31: 1061-1067
  • 64 Guibal A, Boularan C, Bruce M et al. Evaluation of shearwave elastography for the characterisation of focal liver lesions on ultrasound. Eur Radiol 2013; 23: 1138-1149
  • 65 Itoh A, Ueno E, Tohno E et al. Breast disease: clinical application of US elastography for diagnosis. Radiology 2006; 239: 341-350
  • 66 Hatzung G, Grunwald S, Zygmunt M et al. Sonoelastography in the diagnosis of malignant and benign breast lesions: initial clinical experiences. Ultraschall in Med 2010; 31: 596-603
  • 67 Cho N, Jang M, Lyou CY et al. Distinguishing benign from malignant masses at breast US: combined US elastography and color doppler US--influence on radiologist accuracy. Radiology 2012; 262: 80-90
  • 68 Wojcinski S, Farrokh A, Weber S et al. Multicenter study of ultrasound real-time tissue elastography in 779 cases for the assessment of breast lesions: improved diagnostic performance by combining the BI-RADS(R)-US classification system with sonoelastography. Ultraschall in Med 2010; 31: 484-491
  • 69 Zhi H, Xiao XY, Ou B et al. Could ultrasonic elastography help the diagnosis of small (</=2cm) breast cancer with the usage of sonographic BI-RADS classification?. Eur J Radiol 2012; 81: 3216-3221
  • 70 Schaefer FK, Heer I, Schaefer PJ et al. Breast ultrasound elastography--results of 193 breast lesions in a prospective study with histopathologic correlation. Eur J Radiol 2011; 77: 450-456
  • 71 Fischer T, Peisker U, Fiedor S et al. Significant differentiation of focal breast lesions: raw data-based calculation of strain ratio. Ultraschall in Med 2012; 33: 372-379
  • 72 Hall FM. Sonography of the breast: controversies and opinions. Am J Roentgenol 1997; 169: 1635-1636
  • 73 Isermann R, Grunwald S, Hatzung G et al. Breast lesion sizing by B-mode imaging and sonoelastography in comparison to histopathological sizing--a prospective study. Ultraschall in Med 2011; 32: S21-26
  • 74 Barr RG, Destounis S, Lackey LB et al. Evaluation of breast lesions using sonographic elasticity imaging: a multicenter trial. J Ultrasound Med 2012; 31: 281-287
  • 75 Gong X, Xu Q, Xu Z et al. Real-time elastography for the differentiation of benign and malignant breast lesions: a meta-analysis. Breast Cancer Res Treat 2011; 130: 11-18
  • 76 Sadigh G, Carlos RC, Neal CH et al. Accuracy of quantitative ultrasound elastography for differentiation of malignant and benign breast abnormalities: a meta-analysis. Breast Cancer Res Treat 2012; 134: 923-931
  • 77 Booi RC, Carson PL, O'Donnell M et al. Characterization of cysts using differential correlation coefficient values from two dimensional breast elastography: preliminary study. Ultrasound Med Biol 2008; 34: 12-21
  • 78 Cho N, Moon WK, Chang JM et al. Aliasing artifact depicted on ultrasound (US)-elastography for breast cystic lesions mimicking solid masses. Acta Radiol 2011; 52: 3-7
  • 79 Barr RG, Lackey AE. The utility of the "bull's-eye" artifact on breast elasticity imaging in reducing breast lesion biopsy rate. Ultrasound Q 2011; 27: 151-155
  • 80 Barr RG. Shear wave imaging of the breast: still on the learning curve. J Ultrasound Med 2012; 31: 347-350
  • 81 Athanasiou A, Tardivon A, Tanter M et al. Breast lesions: quantitative elastography with supersonic shear imaging – preliminary results. Radiology 2010; 256: 297-303
  • 82 Evans A, Whelehan P, Thomson K et al. Quantitative shear wave ultrasound elastography: initial experience in solid breast masses. Breast Cancer Res 2010; 12: R104
  • 83 Berg WA, Cosgrove DO, Dore CJ et al. Shear-wave elastography improves the specificity of breast US: the BE1 multinational study of 939 masses. Radiology 2012; 262: 435-449
  • 84 Cosgrove DO, Berg WA, Dore CJ et al. Shear wave elastography for breast masses is highly reproducible. Eur Radiol 2011; 22: 1023-1032
  • 85 Schaefer FKW, Berg W, Cosgrove D et al. ShearWave™ Elastography worldwide breast trial model: Can additional SWE-features support downgrading BIRADS 3 to BI-RADS 2’?. Abstract European Congress of Radiology 2012: p216
  • 86 Tozaki M, Isobe S, Sakamoto M. Combination of elastography and tissue quantification using the acoustic radiation force impulse (ARFI) technology for differential diagnosis of breast masses. Jpn J Radiol 2012; 30: 659-670
  • 87 Chang JM, Moon WK, Cho N et al. Breast mass evaluation: factors influencing the quality of US elastography. Radiology 2011; 259: 59-64
  • 88 Cespedes I, Ophir J, Ponnekanti H et al. Elastography: elasticity imaging using ultrasound with application to muscle and breast in vivo. Ultrason Imaging 1993; 15: 73-88
  • 89 Garra BS, Cespedes EI, Ophir J et al. Elastography of breast lesions: initial clinical results. Radiology 1997; 202: 79-86
  • 90 Krouskop TA, Wheeler TM, Kallel F et al. Elastic moduli of breast and prostate tissues under compression. Ultrason Imaging 1998; 20: 260-274
  • 91 Samani A, Zubovits J, Plewes D. Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples. Phys Med Biol 2007; 52: 1565-1576
  • 92 Reiners C, Wegscheider K, Schicha H et al. Prevalence of thyroid disorders in the working population of Germany: ultrasonography screening in 96,278 unselected employees. Thyroid 2004; 14: 926-932
  • 93 Gharib H, Papini E, Paschke R et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J Endocrinol Invest 2010; 33: 51-56
  • 94 Gharib H, Papini E, Paschke R et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and EuropeanThyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules. Endocr Pract 2010; 16: 1-43
  • 95 Asteria C, Giovanardi A, Pizzocaro A et al. US-elastography in the differential diagnosis of benign and malignant thyroid nodules. Thyroid 2008; 18: 523-531
  • 96 Vorlander C, Wolff J, Saalabian S et al. Real-time ultrasound elastography--a noninvasive diagnostic procedure for evaluating dominant thyroid nodules. Langenbecks Arch Surg 2010; 395: 865-871
  • 97 Bojunga J, Herrmann E, Meyer G et al. Real-time elastography for the differentiation of benign and malignant thyroid nodules: a meta-analysis. Thyroid 2010; 20: 1145-1150
  • 98 Moon HJ, Kim EK, Yoon JH et al. Clinical implication of elastography as a prognostic factor of papillary thyroid microcarcinoma. Ann Surg Oncol 2012; 19: 2279-2287
  • 99 Cantisani V, D'Andrea V, Biancari F et al. Prospective evaluation of multiparametric ultrasound and quantitative elastosonography in the differential diagnosis of benign and malignant thyroid nodules: Preliminary Experience. Eur J Radiol 2012; 81: 2678-2683
  • 100 Ning CP, Jiang SQ, Zhang T et al. The value of strain ratio in differential diagnosis of thyroid solid nodules. Eur J Radiol 2012; 81: 286-291
  • 101 Wang Y, Dan HJ, Dan HY et al. Differential diagnosis of small single solid thyroid nodules using real-time ultrasound elastography. J Int Med Res 2010; 38: 466-472
  • 102 Lippolis PV, Tognini S, Materazzi G et al. Is elastography actually useful in the presurgical selection of thyroid nodules with indeterminate cytology?. J Clin Endocrinol Metab 2011; 96: E1826-1830
  • 103 Cantisani V, Ulisse S, Guaitoli E et al. Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology. PLoS One 2012; 7: e50725
  • 104 Sebag F, Vaillant-Lombard J, Berner C et al. Shear wave elastography: a new ultrasound imaging mode for the differential diagnosis of benign and malignant thyroid nodules. J Clin Endocrinol Metab 2010; 95: 5281-5288
  • 105 Bhatia KS, Tong CS, Cho CC et al. Shear wave elastography of thyroid nodules in routine clinical practice: preliminary observations and utility for detecting malignancy. Eur Radiol 2012; 22 (11) 2397-2406
  • 106 Veyrieres JB, Albarel F, Lombard JV et al. A threshold value in Shear Wave elastography to rule out malignant thyroid nodules: a reality?. Eur J Radiol 2012; 81: 3965-3972
  • 107 Bojunga J, Dauth N, Berner C et al. Acoustic radiation force impulse imaging for differentiation of thyroid nodules. PLoS One 2012; 7: e42735
  • 108 Friedrich-Rust M, Romenski O, Meyer G et al. Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: a limited patient feasibility study. Ultrasonics 2012; 52: 69-74
  • 109 Hong Y, Liu X, Li Z et al. Real-time ultrasound elastography in the differential diagnosis of benign and malignant thyroid nodules. J Ultrasound Med 2009; 28: 861-867
  • 110 Rago T, Santini F, Scutari M et al. Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules. J Clin Endocrinol Metab 2007; 92: 2917-2922
  • 111 Kim JK, Baek JH, Lee JH et al. Ultrasound elastography for thyroid nodules: a reliable study?. Ultrasound Med Biol 2012; 38: 1508-1513
  • 112 Nylund K, Hausken T, Gilja OH. Ultrasound and inflammatory bowel disease. Ultrasound Q 2010; 26: 3-15
  • 113 Gilja OH, Heimdal A, Hausken T et al. Strain during gastric contractions can be measured using Doppler ultrasonography. Ultrasound Med Biol 2002; 28: 1457-1465
  • 114 Stidham RW, Xu J, Johnson LA et al. Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease. Gastroenterology 2011; 141: 819-826 e811
  • 115 Rustemovic N, Cukovic-Cavka S, Brinar M et al. A pilot study of transrectal endoscopic ultrasound elastography in inflammatory bowel disease. BMC Gastroenterol 2011; 11: 113
  • 116 Ishikawa D, Ando T, Watanabe O et al. Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis. BMC Gastroenterol 2011; 11: 29
  • 117 Gilja OH. Ultrasound of the stomach--the EUROSON lecture 2006. Ultraschall in Med 2007; 28: 32-39
  • 118 Ahmed AB, Matre K, Hausken T et al. Rome III subgroups of functional dyspepsia exhibit different characteristics of antral contractions measured by strain rate imaging – a pilot study. Ultraschall in Med 2012; 33: E233-240
  • 119 Heimdal A. Strain Rate Imaging- Anew tool for studying the GI tract. In: Odegaard S, Gilja OH, Gregersen H, editors. Basic and new aspects of gastrointestinal ultrasonography. Singapore: World Scientific; 2005: 243-263
  • 120 Matre K, Ahmed AB, Gregersen H et al. In vitro evaluation of ultrasound Doppler strain rate imaging: modification for measurement in a slowly moving tissue phantom. Ultrasound Med Biol 2003; 29: 1725-1734
  • 121 Ahmed AB, Gilja OH, Gregersen H et al. In vitro strain measurement in the porcine antrum using ultrasound doppler strain rate imaging. Ultrasound Med Biol 2006; 32: 513-522
  • 122 Ahmed AB, Gilja OH, Hausken T et al. Strain measurement during antral contractions by ultrasound strain rate imaging: influence of erythromycin. Neurogastroenterol Motil 2009; 21: 170-179
  • 123 Hirche TO, Ignee A, Barreiros AP et al. Indications and limitations of endoscopic ultrasound elastography for evaluation of focal pancreatic lesions. Endoscopy 2008; 40: 910-917
  • 124 Giovannini M, Botelberge T, Bories E et al. Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: a multicenter study. World J Gastroenterol 2009; 15: 1587-1593
  • 125 Săftoiu A, Vilmann P, Gorunescu F et al. Efficacy of an artificial neural network-based approach to endoscopic ultrasound elastography in diagnosis of focal pancreatic masses. Clin Gastroenterol Hepatol 2012; 10: 84-90
  • 126 Janssen J, Schlorer E, Greiner L. EUS elastography of the pancreas: feasibility and pattern description of the normal pancreas, chronic pancreatitis, and focal pancreatic lesions. Gastrointest Endosc 2007; 65: 971-978
  • 127 Larsen MH, Fristrup C, Hansen TP et al. Endoscopic ultrasound, endoscopic sonoelastography, and strain ratio evaluation of lymph nodes with histology as gold standard. Endoscopy 2012; 44: 759-766
  • 128 Allgayer H, Ignee A, Dietrich CF. Endosonographic elastography of the anal sphincter in patients with fecal incontinence. Scand J Gastroenterol 2010; 45: 30-38
  • 129 Waage JE, Havre RF, Odegaard S et al. Endorectal elastography in the evaluation of rectal tumours. Colorectal Dis 2011; 13: 1130-1137
  • 130 Paterson S, Duthie F, Stanley AJ. Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer. World J Gastroenterol 2012; 18: 889-895
  • 131 Fusaroli P, Saftoiu A, Mancino MG et al. Techniques of image enhancement in EUS (with videos). Gastrointest Endosc 2011; 74: 645-655
  • 132 Săftoiu A, Vilmann P, Hassan H et al. Analysis of endoscopic ultrasound elastography used for characterisation and differentiation of benign and malignant lymph nodes. Ultraschall in Med 2006; 27: 535-542
  • 133 Săftoiu A, Vilmann P, Gorunescu F et al. Neural network analysis of dynamic sequences of EUS elastography used for the differential diagnosis of chronic pancreatitis and pancreatic cancer. Gastrointest Endosc 2008; 68: 1086-1094
  • 134 Săftoiu A, Vilmann P, Gorunescu F et al. Accuracy of endoscopic ultrasound elastography used for differential diagnosis of focal pancreatic masses: a multicenter study. Endoscopy 2011; 43: 596-603
  • 135 Larsen MH, Fristrup CW, Mortensen MB. Intra- and interobserver agreement of endoscopic sonoelastography in the evaluation of lymph nodes. Ultraschall in Med 2011; 32: E45-50
  • 136 Dietrich C. Echtzeit-Gewebeelastografie. Anwendungsmöglichkeiten nicht nur im Gastrointestinaltrakt. Endoskopie Heute 2010; 23: 177-212
  • 137 Dietrich CF, Hirche TO, Ott M et al. Real-time tissue elastography in the diagnosis of autoimmune pancreatitis. Endoscopy 2009; 41: 718-720
  • 138 Iglesias-Garcia J, Larino-Noia J, Abdulkader I et al. Quantitative endoscopic ultrasound elastography: an accurate method for the differentiation of solid pancreatic masses. Gastroenterology 2010; 139: 1172-1180
  • 139 Itokawa F, Itoi T, Sofuni A et al. EUS elastography combined with the strain ratio of tissue elasticity for diagnosis of solid pancreatic masses. J Gastroenterol 2011; 46: 843-853
  • 140 Mei M, Ni J, Liu D et al. EUS elastography for diagnosis of solid pancreatic masses: a meta-analysis. Gastrointest Endosc 2012; 77: 578-589
  • 141 Pei Q, Zou X, Zhang X et al. Diagnostic value of EUS elastography in differentiation of benign and malignant solid pancreatic masses: a meta-analysis. Pancreatology 2012; 12: 402-408
  • 142 D'Onofrio M, Gallotti A, Salvia R et al. Acoustic radiation force impulse (ARFI) ultrasound imaging of pancreatic cystic lesions. Eur J Radiol 2011; 80: 241-244
  • 143 Piscaglia F, Nolsoe C, Dietrich CF et al. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): update 2011 on non-hepatic applications. Ultraschall in Med 2012; 33: 33-59
  • 144 Jenssen C, Dietrich CF. Endoscopic ultrasound-guided fine-needle aspiration biopsy and trucut biopsy in gastroenterology – An overview. Best Pract Res Clin Gastroenterol 2009; 23: 743-759
  • 145 Janssen J. [(E)US elastography: current status and perspectives]. Z Gastroenterol 2008; 46: 572-579
  • 146 Janssen J, Dietrich CF, Will U et al. Endosonographic elastography in the diagnosis of mediastinal lymph nodes. Endoscopy 2007; 39: 952-957
  • 147 Xu W, Shi J, Zeng X et al. EUS elastography for the differentiation of benign and malignant lymph nodes: a meta-analysis. Gastrointest Endosc 2011; 74: 1001-1009
  • 148 Kelloff GJ, Choyke P, Coffey DS. Challenges in clinical prostate cancer: role of imaging. Am J Roentgenol Am J Roentgenol 2009; 192: 1455-1470
  • 149 Singh H, Canto EI, Shariat SF et al. Predictors of prostate cancer after initial negative systematic 12 core biopsy. J Urol 2004; 171: 1850-1854
  • 150 Ashley RA, Inman BA, Routh JC et al. Reassessing the diagnostic yield of saturation biopsy of the prostate. Eur Urol 2008; 53: 976-981
  • 151 Onur R, Littrup PJ, Pontes JE et al. Contemporary impact of transrectal ultrasound lesions for prostate cancer detection. J Urol 2004; 172: 512-514
  • 152 Salomon G, Kollerman J, Thederan I et al. Evaluation of prostate cancer detection with ultrasound real-time elastography: a comparison with step section pathological analysis after radical prostatectomy. Eur Urol 2008; 54: 1354-1362
  • 153 Pallwein L, Mitterberger M, Struve P et al. Real-time elastography for detecting prostate cancer: preliminary experience. BJU Int 2007; 100: 42-46
  • 154 Brock M, von Bodman C, Sommerer F et al. Comparison of real-time elastography with grey-scale ultrasonography for detection of organ-confined prostate cancer and extra capsular extension: a prospective analysis using whole mount sections after radical prostatectomy. BJU Int 2012; 108: E217-222
  • 155 Brock M, von Bodman C, Palisaar RJ et al. The impact of real-time elastography guiding a systematic prostate biopsy to improve cancer detection rate: a prospective study of 353 patients. J Urol 2012; 187: 2039-2043
  • 156 Kapoor A, Mahajan G, Sidhu BS. Real-time elastography in the detection of prostate cancer in patients with raised PSA level. Ultrasound Med Biol 2011; 37: 1374-1381
  • 157 Walz J, Marcy M, Pianna JT et al. Identification of the prostate cancer index lesion by real-time elastography: considerations for focal therapy of prostate cancer. World J Urol 2011; 29: 589-594
  • 158 Aigner F, Pallwein L, Junker D et al. Value of real-time elastography targeted biopsy for prostate cancer detection in men with prostate specific antigen 1.25 ng/ml or greater and 4.00 ng/ml or less. J Urol 2010; 184: 913-917
  • 159 Aboumarzouk OM, Ogston S, Huang Z et al. Diagnostic accuracy of transrectal elastosonography (TRES) imaging for the diagnosis of prostate cancer: a systematic review and meta-analysis. BJU Int 2012; 110: 1414-1423
  • 160 Kamoi K, Okihara K, Ochiai A et al. The utility of transrectal real-time elastography in the diagnosis of prostate cancer. Ultrasound Med Biol 2008; 34: 1025-1032
  • 161 Bercoff J, Tanter M, Fink M. Supersonic shear imaging: a new technique for soft tissue elasticity mapping. IEEE Trans Ultrason Ferroelectr Freq Control 2004; 51: 396-409
  • 162 Correas JM, Khairoune A, Tissier AM et al. Trans-rectal quantitative shear wave elastography: application to prostate cancer. A feasibility study. Abstract, European Congress of Radiology, Vienna, 2012
  • 163 Barr RG, Memo R, Schaub CR. Shear wave ultrasound elastography of the prostate: initial results. Ultrasound Q 2012; 28: 13-20
  • 164 Levinson SF, Shinagawa M, Sato T. Sonoelastic determination of human skeletal muscle elasticity. J Biomech 1995; 28: 1145-1154
  • 165 Drakonaki EE, Allen GM, Wilson DJ. Ultrasound elastography for musculoskeletal applications. Br J Radiol 2012; 85: 1435-1445
  • 166 Pedersen M, Fredberg U, Langberg H. Sonoelastography as a Diagnostic Tool in the Assessment of Musculoskeletal Alterations: A Systematic Review. Ultraschall in Med 2012; 33: 441-446
  • 167 Drakonaki EE, Allen GM, Wilson DJ. Real-time ultrasound elastography of the normal Achilles tendon: reproducibility and pattern description. Clin Radiol 2009; 64: 1196-1202
  • 168 De Zordo T, Chhem R, Smekal V et al. Real-time sonoelastography: findings in patients with symptomatic achilles tendons and comparison to healthy volunteers. Ultraschall in Med 2010; 31: 394-400
  • 169 De Zordo T, Fink C, Feuchtner GM et al. Real-time sonoelastography findings in healthy Achilles tendons. Am J Roentgenol Am J Roentgenol 2009; 193: W134-138
  • 170 Tan S, Kudas S, Ozcan AS et al. Real-time sonoelastography of the Achilles tendon: pattern description in healthy subjects and patients with surgically repaired complete ruptures. Skeletal Radiol 2012; 41: 1067-1072
  • 171 Klauser AS, Faschingbauer R, Jaschke WR. Is sonoelastography of value in assessing tendons?. Semin Musculoskelet Radiol 2010; 14: 323-333
  • 172 Klauser AS, Myamoto H, Tamegger M et al. Achilles tendon assessed with sonoelastography: histologic agreement. Radiology 2013; DOI: 10.1148/radiol.13121936.
  • 173 Botar-Jid C, Damian L, Dudea SM et al. The contribution of ultrasonography and sonoelastography in assessment of myositis. Med Ultrason 2010; 12: 120-126
  • 174 Vasilescu D, Dudea S, Botar-Jid C et al. Sonoelastography contribution in cerebral palsy spasticity treatment assessment, preliminary report: a systematic review of the literature apropos of seven patients. Med Ultrason 2010; 12: 306-310
  • 175 Kwon DR, Park GY, Lee SU et al. Spastic cerebral palsy in children: dynamic sonoelastographic findings of medial gastrocnemius. Radiology 2012; 263: 794-801
  • 176 Park GY, Kwon DR. Sonoelastographic evaluation of medial gastrocnemius muscles intrinsic stiffness after rehabilitation therapy with botulinum toxin a injection in spastic cerebral palsy. Arch Phys Med Rehabil 2012; 93: 2085-2089
  • 177 Bhatia KS, Tong CS, Cho CC et al. Shear wave elastography of thyroid nodules in routine clinical practice: preliminary observations and utility for detecting malignancy. Eur Radiol 2012; 22: 2397-2406
  • 178 Lyshchik A, Higashi T, Asato R et al. Cervical lymph node metastases: diagnosis at sonoelastography--initial experience. Radiology 2007; 243: 258-267
  • 179 Selbekk T, Bang J, Unsgaard G. Strain processing of intraoperative ultrasound images of brain tumours: initial results. Ultrasound Med Biol 2005; 31: 45-51
  • 180 Chakraborty A, Bamber JC, Dorward NL. Preliminary investigation into the use of ultrasound elastography during brain tumour resection. Ultrasound 2012; 20: 33-40
  • 181 House M, Feltovich H, Hall TJ et al. Three-dimensional, extended field-of-view ultrasound method for estimating large strain mechanical properties of the cervix during pregnancy. Ultrason Imaging 2012; 34: 1-14
  • 182 Kantarci F, Cebi OlgunD, Mihmanli I. Shear-wave elastography of segmental infarction of the testis. Korean J Radiol 2012; 13: 820-822
  • 183 Allgayer H, Zipse S, Crispin A et al. Endorectal ultrasound and real-time elastography in patients with fecal incontinence following anorectal surgery: A prospective comparison evaluating short- and long-term outcomes in irradiated and non-irradiated patients. Z Gastroenterol 2012; 50: 1281-1286
  • 184 Dietrich CF, Barreiros AP, Nuernberg D et al. [Perianal ultrasound]. Z Gastroenterol 2008; 46: 625-630
  • 185 Maurice RL, Soulez G, Giroux MF et al. Noninvasive vascular elastography for carotid artery characterization on subjects without previous history of atherosclerosis. Med Phys 2008; 35: 3436-3443
  • 186 Couade M, Pernot M, Prada C et al. Quantitative assessment of arterial wall biomechanical properties using shear wave imaging. Ultrasound Med Biol 2010; 36: 1662-1676
  • 187 De Zordo T, Lill SR, Fink C et al. Real-time sonoelastography of lateral epicondylitis: comparison of findings between patients and healthy volunteers. Am J Roentgenol Am J Roentgenol 2009; 193: 180-185
  • 188 Wu CH, Chang KV, Mio S et al. Sonoelastography of the plantar fascia. Radiology 2011; 259: 502-507
  • 189 Miyamoto H, Miura T, Isayama H et al. Stiffness of the first annular pulley in normal and trigger fingers. J Hand Surg Am 2011; 36: 1486-1491
  • 190 Sikdar S, Shah JP, Gebreab T et al. Novel applications of ultrasound technology to visualize and characterize myofascial trigger points and surrounding soft tissue. Arch Phys Med Rehabil 2009; 90: 1829-1838
  • 191 Arda K, Ciledag N, Aktas E et al. Quantitative assessment of normal soft-tissue elasticity using shear-wave ultrasound elastography. Am J Roentgenol Am J Roentgenol 2011; 197: 532-536
  • 192 Landis JR, Koch GG. An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 1977; 33: 363-374