Secretory Phospholipase A2 Is Associated with the Odds of Acute Coronary Syndromes through Elevation of Serum Amyloid-A Protein

Anwar Santoso; Marita Kaniawati; Syakib Bakri; Irawan Yusuf

doi:10.1055/s-0033-1334093

International Journal of Angiology, Table of Contents

Int J Angiol 2013; 22(01): 049-054
DOI: 10.1055/s-0033-1334093

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Secretory Phospholipase A2 Is Associated with the Odds of Acute Coronary Syndromes through Elevation of Serum Amyloid-A Protein

Anwar Santoso

¹Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Harapan Kita Hospital, National Cardiovascular Centre, Jakarta, Indonesia

,

Marita Kaniawati

²School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia

,

Syakib Bakri

³Department of Internal Medicine, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

,

Irawan Yusuf

⁴Department of Physiology, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia

› Author Affiliations

Abstract

In coronary heart disease (CHD), levels of secretory phospholipase A2 (sPLA2) are commonly increased. Serum amyloid-A (SAA) is increased in acute coronary syndromes (ACS) as well. It is needed to verify the hypotheses that sPLA2 is associated with the odds of ACS through elevation of SAA. We conducted a case–control study with 57 male patients with ACS and 30 controls matched by gender category. Levels of sPLA2, SAA, and myeloperoxidase (MPO) were measured by immunoreactive assay on the basis of a double-antibody sandwich technique. Levels of sPLA2, MPO, and SAA were significantly higher in patients than those in controls (11,359.0 ± 10,372.4 pg/mL vs. 1,320.5 ± 654.5 pg/mL, p = 0.00; 438.6 ± 310.7 ng/mL vs. 271.1 ± 176.8 ng/mL, p = 0.01; 10,995.2 ± 2,842.6 ng/mL vs. 3,861.7 ± 3,173.5 ng/mL, p = 0.00). There were significant correlations between age, visceral obesity, MPO, sPLA2, and SAA (r = 0.43; p = 0.00; r = 0.30; p = 0.00; r = 0.28; p = 0.00 and r = 0.53; p = 0.00). On multivariate logistic regression analyses, there were significant and independent associations between sPLA2 and SAA with odds of ACS [OR (95% CI) = 14.2 (2.1 to 98.6), p = 0.00; OR (95% CI) = 44.9 (6.9 to 328.4), p = 0.00]. Our findings suggest that sPLA2 may be associated with the odds of ACS compared with controls through increased inflammation, represented by elevated SAA.

Keywords

acute coronary syndromes - secretory phospholipase A2 - myeloperoxidase - serum amyloid-A - coronary heart disease - case–control study - odds ratio

Full Text

References

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