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Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin 2013; 23(02): 115-119
DOI: 10.1055/s-0032-1333223
Wissenschaft und Forschung
© Georg Thieme Verlag KG Stuttgart · New York

Electrical Muscle Stimulation Normalizes Blood Glucose Level in Streptozotocin-induced Diabetic Rats

Elektrische Muskelstimulation normalisiert den Blutglukosespiegel eines Streptozotocin-induzierten Diabetes bei Ratten
W.-Z. Lu
1   Department of Biomedical Engineering, Xi’an Technological University, Xi’an, Shaanxi Province, China
,
Y. Ni
1   Department of Biomedical Engineering, Xi’an Technological University, Xi’an, Shaanxi Province, China
,
X.-Y. Meng
1   Department of Biomedical Engineering, Xi’an Technological University, Xi’an, Shaanxi Province, China
› Author Affiliations
Further Information

Publication History

received: 06 September 2012

accepted: 09 November 2012

Publication Date:
10 April 2013 (online)

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Abstract

Background:

Patients with diabetes suffer from slow-to-heal wounds, which often necessitate amputation. Electrical stimulation has been shown to reduce the healing time in such patients.

Objectives:

This study aimed to determine the effect of electrical muscle stimulation on insulin resistance, glucose absorption, and blood lipids in type 2 diabetic rat model.

Methods:

Diabetic rats and normal rats were treated with electrical muscle stimulation (10 Hz, 2 mA, 20 ms) for 40 days. Blood glucose, lipids, insulin and resistin were measured to evaluate antidiabetic activity of electrical stimulation.

Results:

Diabetic rats treated with electrical muscle stimulation resulted in a significant decrease in the concentration of plasma total cholesterol and triglycerides, improved the body weight. Furthermore, electrical stimulation markedly decreased blood glucose level in the diabetic rats. The levels of plasma insulin and resistin exhibited significantly lower in the diabetic rats treated with electrical stimulation than those of the model group. Extending the stimulation up to 20 min from 10 min did not cause significant changes in all the measured blood biochemistry indices and body weight.

Conclusions:

This study showed that electrical muscle stimulation can improve adipose metabolic disturbance in the experimental type 2 ­diabetic rats, can effectively ameliorate insulin resistance and plasma glucose transport by decreasing the levels of plasma resistin.

Zusammenfassung

Hintergrund:

Patienten mit Diabetes leiden unter schlecht heilenden Wunden, welche oft zu Amputationen führen. Elektrostimulation zeigt eine Verkürzung der Wundheilungszeit bei diesen Patienten.

Gegenstand:

Die Studie untersucht die Wirkung einer Elektrostimulation auf die Insulinresistenz, Glukoseabsorption und die Blutfettwerte bei einem Typ-2-Diabetes-Modell der Ratte.

Methode:

Ratten mit Diabetes und gesunde Ratten wurden mit einer elektrischen Muskel­stimulation (10  Hz, 2  mA, 20  ms) 40  Tage behandelt. Blutglukose, Fettwerte, Insulin und Resistin wurden zur Bewertung der antidiabetischen Wirkung dieser Elektrostimulation bestimmt.

Ergebnisse:

Die Ratten mit Diabetes und Muskelstimulation zeigen einen signifikanten Abfall der Plasmakonzentration von Gesamt­cholesterin und Triglyceriden und Verbesserung des Körpergewichts. Außerdem senkt die Elek­trostimulation den Blutglukosespiegel bei den Ratten mit Diabetes. Die Blutkonzentrationen von Insulin und Resistin sind signifikant nie­d­riger in der Gruppe der Ratten mit Diabetes und Elektrostimulation als in der Vergleichsgruppe. Eine Verlängerung der Behandlungszeit von 10 auf 20  min pro Tag ergibt keine signifikanten Änderungen der gemessenen Blutwerte und des Körpergewichts.

Schlussfolgerungen:

Die Studie zeigt, dass muskuläre Elektrostimulation die Fettstoffwechsel Störung im experimentellen Tiermodell (Ratte) des Typ-2-Diabetes verbessern kann; es kann die Insulinresistenz und den Plasma-Glukose-Transport durch Reduktion des Plasma-Resistin-Spiegels wirksam verbessern.

Key words

electrical stimulation - glucose - insulin - resistin

Schlüsselwörter

Elektrostimulation - Glukose - Insulin - Resistin
 

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