Unraveling Mechanisms that Control Platelet Production

Joseph E. Italiano Jr.

doi:10.1055/s-0032-1331157

Seminars in Thrombosis and Hemostasis, Table of Contents

Semin Thromb Hemost 2013; 39(01): 015-024
DOI: 10.1055/s-0032-1331157

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Unraveling Mechanisms that Control Platelet Production

Joseph E. Italiano Jr.

¹Division of Hematology, Brigham and Women's Hospital, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts

› Author Affiliations

Abstract

Platelets are formed by giant precursor cells called megakaryocytes that reside within the bone marrow. The generation of platelets, and their release into the bloodstream by megakaryocytes, requires a complex series of remodeling events powered by the cytoskeleton to result in the release of many platelets from a single megakaryocyte. Abnormalities in this process can result in thrombocytopenia (low platelet count) and can lead to increased risk of bleeding. This review describes the process of platelet production in detail and discusses new insights into novel platelet biology.

Keywords

megakaryocyte - platelet - proplatelet - thrombopoiesis - cytoskeleton

Full Text

References

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