Download PDF
Neuropediatrics 2013; 44(04): 199-202
DOI: 10.1055/s-0032-1330854
Short Communication
Georg Thieme Verlag KG Stuttgart · New York

A Child with Three Episodes of Reversible Splenial Lesion

Takeshi Kouga
1   Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Japan
,
Mizue Iai
1   Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Japan
,
Sumimasa Yamashita
1   Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Japan
,
Noriko Aida
2   Division of Radiology, Kanagawa Children's Medical Center, Yokohama, Japan
,
Jun-ichi Takanashi
3   Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
,
Hitoshi Osaka
1   Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Japan
› Author Affiliations
Further Information

Publication History

06 May 2012

08 October 2012

Publication Date:
19 December 2012 (online)

    Permissions and Reprints

Abstract

In this study, we report the case of an 8-year-old girl who had three episodes of reversible splenial lesion of the corpus callosum (SCC) in 2 years. Vomiting, hypoglycemia, and fever were followed by altered consciousness and diminished muscle tone. In each episode, the clinical manifestations and abnormalities detected during magnetic resonance imaging resolved in 2 weeks. Transient alteration of vision and spike discharges revealed by interictal electroencephalogram implied the SCC lesions were related to epileptic activities. At follow-up, the patient had not presented with SCC lesions or altered consciousness for more than 4 years after undergoing carbamazepine treatment. Our case is the first report of a patient who presented with three episodes of reversible splenial lesion.

Keywords

encephalitis - encephalopathy - corpus callosum - splenium - reversible - epilepsy
 

  • References

  • 1 Tada H, Takanashi J, Barkovich AJ , et al. Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology 2004; 63 (10) 1854-1858
    CrossrefPubMedGoogle Scholar
  • 2 Yeh IB, Tan LCS, Sitoh YY. Reversible splenial lesion in clinically mild encephalitis. Singapore Med J 2005; 46 (12) 726-730
    PubMedGoogle Scholar
  • 3 Takanashi J, Imamura A, Hayakawa F, Terada H. Differences in the time course of splenial and white matter lesions in clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). J Neurol Sci 2010; 292 (1–2) 24-27
    CrossrefPubMedGoogle Scholar
  • 4 Gürtler S, Ebner A, Tuxhorn I, Ollech I, Pohlmann-Eden B, Woermann FG. Transient lesion in the splenium of the corpus callosum and antiepileptic drug withdrawal. Neurology 2005; 65 (7) 1032-1036
    CrossrefPubMedGoogle Scholar
  • 5 Mirsattari SM, Lee DH, Jones MW, Blume WT. Transient lesion in the splenium of the corpus callosum in an epileptic patient. Neurology 2003; 60 (11) 1838-1841
    CrossrefPubMedGoogle Scholar
  • 6 Parikh NC, Kulkarni M. Transient and reversible focal lesion involving the splenium of the corpus callosum in a person with epilepsy. Ann Indian Acad Neurol 2008; 11 (2) 123-124
    CrossrefPubMedGoogle Scholar
  • 7 Vollmann H, Hagemann G, Mentzel HJ, Witte OW, Redecker C. Isolated reversible splenial lesion in tick-borne encephalitis: a case report and literature review. Clin Neurol Neurosurg 2011; 113 (5) 430-433
    CrossrefPubMedGoogle Scholar
  • 8 Morioka S, Otabe O, Uehara H , et al. Recurrence of transient splenial lesions in a child with “benign convulsions with gastroenteritis”. [in Japanese] No To Hattatsu 2010; 42 (6) 449-453
    PubMedGoogle Scholar