Download PDF
Eur J Pediatr Surg 2014; 24(02): 184-186
DOI: 10.1055/s-0032-1330846
Case Gallery
Georg Thieme Verlag KG Stuttgart · New York

A Rare Case of Neonatal Intussusception Caused by Cytomegalovirus

Ruichong Ma
1   Department of Paediatric Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom
,
Mostayn Alam
1   Department of Paediatric Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom
,
Maurizio Pacilli
1   Department of Paediatric Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom
,
Elizabeth Hook
2   Department of Pathology, Addenbrooke's Hospital, Cambridge, United Kingdom
,
Anita Nagy
2   Department of Pathology, Addenbrooke's Hospital, Cambridge, United Kingdom
,
Daniel Carroll
1   Department of Paediatric Surgery, Addenbrooke's Hospital, Cambridge, United Kingdom
› Author Affiliations
Further Information

Publication History

22 July 2012

18 September 2012

Publication Date:
21 November 2012 (online)

Also available at
    Permissions and Reprints

Introduction

Intussusception in neonates is a rare representing less than 1% of all cases of intussusception and making up for less than 3% of neonatal bowel obstructions. Clinical features are vague, such as abdominal distension, bilious vomiting, and bloody stools, hence the possible misdiagnosis of necrotizing enterocolitis (NEC). It is most commonly ileoileal, compared with ileocolic in the older age groups.[1]

In the absence of a definite lead point, the etiology of neonatal intussusception is mostly unknown with some evidence in the literature suggesting a link with different viral infections. Here, we present a unique case of intussusception caused by a cytomegalovirus (CMV) infection in a newborn twin.

 

  • References

  • 1 Görgen-Pauly U, Schultz C, Kohl M, Sigge W, Möller J, Gortner L. Intussusception in preterm infants: case report and literature review. Eur J Pediatr 1999; 158 (10) 830-832
    CrossrefPubMedGoogle Scholar
  • 2 Wang NL, Yeh ML, Chang PY , et al. Prenatal and neonatal intussusception. Pediatr Surg Int 1998; 13 (4) 232-236
    CrossrefPubMedGoogle Scholar
  • 3 Ueki I, Nakashima E, Kumagai M , et al. Intussusception in neonates: analysis of 14 Japanese patients. J Paediatr Child Health 2004; 40 (7) 388-391
    CrossrefPubMedGoogle Scholar
  • 4 Slam KD, Teitelbaum DH. Multiple sequential intussusceptions causing bowel obstruction in a preterm neonate. J Pediatr Surg 2007; 42 (7) 1279-1281
    CrossrefPubMedGoogle Scholar
  • 5 Martínez Biarge M, García-Alix A, Luisa del Hoyo M , et al. Intussusception in a preterm neonate; a very rare, major intestinal problem—systematic review of cases. J Perinat Med 2004; 32 (2) 190-194
    PubMedGoogle Scholar
  • 6 Avansino JR, Bjerke S, Hendrickson M, Stelzner M, Sawin R. Clinical features and treatment outcome of intussusception in premature neonates. J Pediatr Surg 2003; 38 (12) 1818-1821
    CrossrefPubMedGoogle Scholar
  • 7 Murphy TV, Gargiullo PM, Massoudi MS , et al; Rotavirus Intussusception Investigation Team. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med 2001; 344 (8) 564-572
    CrossrefPubMedGoogle Scholar
  • 8 Zanardi LR, Haber P, Mootrey GT, Niu MT, Wharton M. Intussusception among recipients of rotavirus vaccine: reports to the vaccine adverse event reporting system. Pediatrics 2001; 107 (6) E97
    CrossrefPubMedGoogle Scholar
  • 9 Hsu HY, Kao CL, Huang LM , et al. Viral etiology of intussusception in Taiwanese childhood. Pediatr Infect Dis J 1998; 17 (10) 893-898
    CrossrefPubMedGoogle Scholar
  • 10 Guarner J, de Leon-Bojorge B, Lopez-Corella E , et al. Intestinal intussusception associated with adenovirus infection in Mexican children. Am J Clin Pathol 2003; 120 (6) 845-850
    CrossrefPubMedGoogle Scholar
  • 11 Pischke S, Tutarel O, Greten TF , et al. [CMV-enterocolitis as a cause for repeated intestinal intussusceptions in an adult patient after liver transplantation?]. Z Gastroenterol 2010; 48 (6) 688-692
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Zupancic JA, Pennie RA, Issenman R. Intussusception in a child with cytomegalovirus infection. Pediatr Infect Dis J 1994; 13 (6) 548-549
    CrossrefPubMedGoogle Scholar
  • 13 Dollard SC, Grosse SD, Ross DS. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection. Rev Med Virol 2007; 17 (5) 355-363
    CrossrefPubMedGoogle Scholar
  • 14 Boppana SB, Ross SA, Shimamura M , et al; National Institute on Deafness and Other Communication Disorders CHIMES Study. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med 2011; 364 (22) 2111-2118
    CrossrefPubMedGoogle Scholar
  • 15 Paradiž KR, Seme K, Puklavec E, Paro-Panjan D, Poljak M. Prevalence of congenital cytomegalovirus infection in Slovenia: a study on 2,841 newborns. J Med Virol 2012; 84 (1) 109-115
    CrossrefPubMedGoogle Scholar
  • 16 Quiros-Tejeira RE, Ament ME, Rivera-Penera T, Cortina G, Vargas JH. Cytomegalovirus enterocolitis in an immunocompetent infant host: another cause of treatable intractable diarrhea in infancy. J Pediatr Gastroenterol Nutr 1999; 29 (1) 86-90
    CrossrefPubMedGoogle Scholar
  • 17 Ekema G, Pedersini P, Milianti S, Ubertazzi M, Minoli D, Manciana A. Colonic stricture mimicking Hirschsprung's disease: a localized cytomegalovirus infection. J Pediatr Surg 2006; 41 (4) 850-852
    CrossrefPubMedGoogle Scholar
  • 18 Hinds R, Brueton MJ, Francis N, Fell JM. Another cause of bloody diarrhoea in infancy: cytomegalovirus colitis in an immunocompetent child. J Paediatr Child Health 2004; 40 (9-10) 581-582
    CrossrefPubMedGoogle Scholar