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Arzneimittelforschung 2012; 62(12): 650-654
DOI: 10.1055/s-0032-1330018
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Zeolite Nano-Materials and Artichoke (Cynara scolymus L.) Leaf Extract on Increase in Urinary Clearance of Systematically Absorbed Nicotine

R. E. Malekshah
1   Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran
,
R. Mahjub
2   Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3   School of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran
,
M. Rastgarpanah
4   Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
,
M. Ghorbani
5   Danish Technical University of Denmark, Copenhagen, Denmark
,
A. R. Partoazar
6   Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
S. E. Mehr
6   Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
A. R. Dehpour
6   Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
,
F. A. Dorkoosh
2   Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
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Publikationsverlauf

received 02. Juli 2012

accepted 17. Oktober 2012

Publikationsdatum:
29. November 2012 (online)

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Abstract

Nicotine, the main pharmacologically active component in tobacco and cigarette, has some toxic effects and also high potential for addiction. In this study, the effect of artichoke (Cynara scolymus L.) and zeolite nano-materials on urinary excretion of nicotine and consequently elimination of systematically absorbed nicotine was investigated. A simple, valid and highly sensitive high performance liquid chromatography method has been developed for determination of nicotine in rat urine according to guidelines for bioanalysis.

It was found that nano-zeolites can cause increase in urinary concentration of nicotine due to its high surface adsorption. Artichoke leaf extract can cause increase in urinary excretion of nicotine in longer post administration times. It was observed that co-administration of nanozeolites and the leaf extract has the synergetic effect on increasing the urinary excretion of nicotine.

Key words

nicotine - high performance liquid chromatography - artichoke leaf extracts (ALE) - zeolite nano-materials
 

  • References

  • 1 Hoofnagle AN, Laha TJ, Rainey PM et al. Specific Detection of Anabasine, Nicotine, and Nicotine Metabolites in Urine by Liquid Chromatography – Tandem Mass Spectrometry. Am J Clin Pathol 2006; 126: 880-887
    CrossrefPubMedSuche in Google Scholar
  • 2 Ejaz S, Lim CW. Toxicological overview of cigarettesmoking on angiogenesis. Environ Toxicol Pharmacol 2005; 20: 335-344
    CrossrefPubMedSuche in Google Scholar
  • 3 Sreekala S, Indira M. Effect of exogenous selenium on nicotine induced hyperlipidemia in rats. Indian J Physiol Pharmacol 2008; 52: 132-140
    PubMedSuche in Google Scholar
  • 4 Jung BH, Chung BC, Chung SJ et al. Prolonged delivery of nicotine in rats via nasal administration of proliposomes. J Control Release 2000; 66: 73-79
    CrossrefPubMedSuche in Google Scholar
  • 5 Miyazawa M, Kawauchi Y, Okuno Y et al. The novel assay method for nicotine metabolism to cotinine using highperformance liquid chromatography. Chem Pharm Bull 2011; 59: 295-297
    CrossrefPubMedSuche in Google Scholar
  • 6 André JM, Gulick D, Portugal GS et al. Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6mice. Behav Brain Res 2008; 190: 174-181
    CrossrefPubMedSuche in Google Scholar
  • 7 Ceccarelli N, Curadi M, Picciarelli P et al. Globe artichoke as a functional food. Mediterr J Nutr Metab 2010; 3: 197-201
    CrossrefPubMedSuche in Google Scholar
  • 8 Coinu R, Carta S, Urgeghe PP et al. Dose-effect study on the antioxidant properties of leaves and outer bracts of extracts obtained from Violetto di Toscana artichoke. Food Chem 2007; 101: 524-531
    CrossrefPubMedSuche in Google Scholar
  • 9 Chevallier A. Encyclopedia of Medicinal Plants. Dorling Kindersley Ltd.; London: 2001
    Suche in Google Scholar
  • 10 Leung A.Y, Foster S. Encyclopedia of Common Natural Ingredients Used in Food and Cosmetics. John Wiley & Sons Inc.; 2nd edn. 1996
    Suche in Google Scholar
  • 11 Lattanzio V, Kroon PA, Linsalata V et al. Globe artichoke: A functional food and source of nutraceutical ingredients. Journal of Functional Foods 2009; 1: 131-144
    CrossrefPubMedSuche in Google Scholar
  • 12 Azzini E, Bugianesi R, Romano F et al. Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in hum an subjects: a pilot study. Br J Nutr 2007; 97: 963-969
    CrossrefPubMedSuche in Google Scholar
  • 13 Wider B, Pittler MH, Thompson-Coon J et al. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database Syst Rev 2009; 4 CD003335
    PubMedSuche in Google Scholar
  • 14 Thompson Coon J, Ernst E. Herbs for serum cholesterol reduction: a systematic view. J Fam Pract 2003; 52: 468-478
    PubMedSuche in Google Scholar
  • 15 Jun NJ, Jang KC, Kim SC et al. Radical Scavenging Activity and Content of Cynarin(1, 3-dicaffeoylquinic acid) in Artichoke (Cynarascolymus L.). J Appl Biol Chem 2007; 50: 244-248
    PubMedSuche in Google Scholar
  • 16 Pandino G, Courts FL, Lombardo S et al. Caffeoylquinic acids and flavonoids in the immature inflorescence of globe artichoke, wild cardoon and cultivated cardoon. J Agric Food Chem 2010; 58: 1026-1031
    CrossrefPubMedSuche in Google Scholar
  • 17 Yu T, Zhang Y, You C et al. Controlled nanozeolite-assembled electrode: remarkable enzyme immobilization ability and high sensitivity as biosensor. Chem Eur J 2006; 12: 1137-1143
    CrossrefPubMedSuche in Google Scholar
  • 18 Xu F, Wang Y, Wang X et al. A novel hierarchical nanozeolite composite as sorbent for protein separation in immobilized metal-ion affinity chromatography. Adv Mater 2003; 15: 1751-1753
    CrossrefPubMedSuche in Google Scholar
  • 19 Jawor A, Jeong BH, Hoek EMV. Synthesis, characterization, and ion-exchange properties of colloidal zeolite nanocrystals. J Nanopart Res 2009; 11: 1795-1803
    CrossrefPubMedSuche in Google Scholar
  • 20 Kuzniatsova T, Kim Y, Shqau K et al. Zeta potential measurements of zeolite Y: Application in homogeneous deposition of particle coatings. Microporous and Mesoporous Materials 2007; 103: 102-107
    CrossrefPubMedSuche in Google Scholar
  • 21 Ceppa F, Jahiri YE, Mayaudon H et al. High-performance liquid chromatographic determination of cotinine in urine in isocratic mode. J Chromatogr B Biomed Sci App 2000; 746: 115-122
    CrossrefPubMedSuche in Google Scholar
  • 22 Ok YS, Yang JE, Zhang YS et al. Heavy metal adsorption by a formulated zeolite-Portland cements mixture. J Hazard Mater 2007; 147: 91-96
    CrossrefPubMedSuche in Google Scholar
  • 23 Xu YH, Nakajima T, Ohki A. Adsorption and removal of arsenic (V) from drinking water by aluminum-loaded Shirasu-zeolite. J Hazard Mater 2002; B 92: 275-287
    CrossrefPubMedSuche in Google Scholar
  • 24 Xu Y, Zhu JH, Ma LL et al. Removing nitrosamines from mainstream smoke of cigarettes by zeolites. Microporous and Mesoporous Materials 2003; 60: 125-138
    CrossrefPubMedSuche in Google Scholar
  • 25 Meier WM, Siegmann K. Significant reduction of carcinogenic compounds in tobacco smoke by the use of zeolite catalysts. Microporous and Mesoporous Materials 1999; 33: 307-310
    CrossrefPubMedSuche in Google Scholar
  • 26 Modirsanei M, Khosravi AR, Kiaei SMM et al. Efficacy of dietary natural zeolite and SCE in counteracting aflatoxicosis in broiler chicks. Journal of Applied Animal Research 2004; 26: 39-44
    CrossrefPubMedSuche in Google Scholar
  • 27 Shabani A, Dastar B, Khomeiri M et al. Response of broiler chickens to different levels of nanozeolite during experimental aflatoxicosis. Journal of Biological Sciences 2010; 10: 362-367
    CrossrefPubMedSuche in Google Scholar
  • 28 Miazzo R, Rosa CAR, Carvalho ECQ et al. Efficacy of synthetic zeolite to reduce the toxicity of AF in broiler chicks. Poultry Science 2000; 79: 1-6
    PubMedSuche in Google Scholar
  • 29 Karampahtsis E. Zeolite: A randomized controlled trial to investigate the effectiveness and safety as an oral chelating agent for heavy metals – A comparison between different commercially available preparations. 2011; ISRCTN12861674
    PubMedSuche in Google Scholar
  • 30 Joy JF, Haber SL. Clinical uses of artichoke leaf extract. Am J Health Syst Pharm 2007; 64: 1904-1909
    CrossrefPubMedSuche in Google Scholar