Klin Monbl Augenheilkd 2013; 230(2): 127-132
DOI: 10.1055/s-0032-1327946
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Wirkmechanismen, klinisches Profil und Stellenwert von Prostaglandin- und Prostamid-Analoga in der antiglaukomatösen Therapie

Mechanisms, Clinical Profile and Role of Prostaglandin and Prostamide Analogues in Antiglaucomatous Therapy
A. Yu
1   Augenklinik, Ludwig-Maximilians-Universität, München
,
U. Welge-Lüßen
2   Augenklinik, Universität Erlangen-Nürnberg, Erlangen
› Institutsangaben
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Publikationsverlauf

eingereicht 29. August 2012

akzeptiert 17. Oktober 2012

Publikationsdatum:
20. Januar 2013 (online)

Zusammenfassung

Prostaglandin- und Prostamid-Analoga gehören zu einer neueren Gruppe von Substanzen, die in den 1990er-Jahren auf den Markt kamen. Sie haben die antiglaukomatöse Therapie durch ihre einfache Dosierung und ihren geringeren Nebenwirkungen revolutioniert. Heute sind Prostaglandin- und Prostamid-Analoga als First-Line-Therapie bei Patienten mit primären Offenwinkelglaukom und okulärer Hypertension zugelassen. Sie senken den intraokularen Druck primär über die Erhöhung des uveoskleralen Abflusses. Allerdings zeigen neuere Untersuchungen, dass sie auch einen Einfluss auf die trabekuläre Abflussfazilität haben und damit die konventionellen Abflusswege verbessern können. Prostaglandin- und Prostamid-Analoga zeichnen sich durch eine hohe Effizienz in der intraokularen Drucksenkung aus, die der von den anderen antiglaukomatösen Substanzgruppen überlegen ist. Sie scheinen insbesondere durch die primäre Abflussverbesserung eine gute Kontrolle von Druckfluktuationen über 24 Stunden zu haben. Des Weiteren haben sie geringere systemische Nebenwirkungen als β-Blocker. Ihr Einsatz ist allerdings mit höheren Kosten verbunden. Im Fall von unerwünschten Ereignissen gehen sie vor allem mit okulären Symptomen einher. Somit haben Prostaglandin- und Prostamid-Analoga aufgrund ihres guten klinischen Profils einen festen Stellenwert als primäre oder ergänzende Therapie in der Behandlung von Glaukomerkrankungen.

Abstract

Prostaglandin and prostamide analogues belong to a new substance group which came into the market in the 1990s. They have revolutionised antiglaucomatous therapy by their once-daily dosing regimen and fewer side effects. Today, prostaglandin and prostamide analogues are approved as first-line therapy for patients with primary open-angle glaucoma and ocular hypertension. They lower the intraocular pressure primarily by increasing the uveoscleral outflow. Recent investigations have shown that they also improve the trabecular outflow facility and thus the conventional outflow pathways. Prostaglandin and prostamide analogues are highly efficient in lowering the intraocular pressure, for which they are superior to other antiglaucomatous substance groups. In particular, they appear to have a good control of 24-hour intraocular pressure fluctuations by primarily improving the outflow pathways. Furthermore, they have less systemic side effects than β-blockers. However, their use is often associated with higher costs. In case of undesirable events, they mostly present with ocular symptoms. Based on their good clinical profile, prostaglandin and prostamide analogues play an important role in the primary and additive therapy for glaucoma.

 
  • Literatur

  • 1 Camras CB, Bito LZ. Reduction of intraocular pressure in normal and glaucomatous primate (Aotus trivirgatus) eyes by topically applied prostaglandin F . Curr Eye Res 1981; 1: 205-209
  • 2 Alm A. Prostaglandin derivates as ocular hypotensive agents. Prog Retin Eye Res 1998; 17: 291-312
  • 3 Giuffré G. The effects of prostaglandin F in the human eye. Graefeʼs Arch Clin Exp Ophthalmol 1985; 222: 139-141
  • 4 Ishida N, Odani-Kawabata N, Shimazaki A et al. Prostanoids in the therapy of glaucoma. Cardiovasc Drug Rev 2006; 241: 1-10
  • 5 Crowston JG, Lindsey JD, Morris CA et al. Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. Invest Ophthalmol Vis Sci 2005; 46: 4571-4577
  • 6 Ota T, Aihara M, Narumiya S et al. The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Invest Ophthalmol Vis Sci 2005; 46: 4159-4163
  • 7 Camras CB, Toris CB, Sjoquist B et al. Detection of the free acid of bimatoprost in aqueous humor samples from human eyes treated with bimatoprost before cataract surgery. Ophthalmology 2004; 111: 2193-2198
  • 8 Costagliola C, dellʼOmo R, Romano MR et al. Pharmacotherapy of intraocular pressure – part II. Carbonic anhydrase inhibitors, prostaglandin analogues and prostamides. Expert Opin Pharmacother 2009; 10: 2859-2870
  • 9 Ooi YH, Oh DJ, Rhee DJ. Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest Ophthalmol Vis Sci 2009; 50: 5259-5265
  • 10 Richter M, Krauss AH, Woodward DF et al. Morphological changes in the anterior eye segment after long-term treatment with different receptor selective prostaglandin agonists and a prostamide. Invest Ophthalmol Vis Sci 2003; 44: 4419-4426
  • 11 Kim JW, Lindsey JD, Wang N et al. Increased human scleral permeability with prostaglandin exposure. Invest Ophthalmol Vis Sci 2001; 427: 1514-1521
  • 12 Oh DJ, Martin JL, Williams AJ et al. Effect of latanoprost on the expression of matrix metalloproteinases and their tissue inhibitors in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 2006; 47: 3887-3895
  • 13 Bahler CK, Howell KG, Hann CR et al. Prostaglandins increase trabecular meshwork outflow facility in cultured human anterior segments. Am J Ophthalmol 2008; 145: 114-119
  • 14 Thieme H, Schimmat C, Münzer G et al. Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility. Invest Ophthalmol Vis Sci 2006; 47: 938-945
  • 15 van der Valk R, Webers CA, Schouten JS et al. Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials. Ophthalmology 2005; 112: 1177-1185
  • 16 Bean GW, Camras CB. Commercially available prostaglandin analogs for the reduction of intraocular pressure: similarities and differences. Surv Ophthalmol 2008; 53: S69-S84
  • 17 Lindén C, Alm A. Latanoprost twice daily is less effective than once daily : indication of receptor subsensitivity?. Curr Eye Res 1998; 17: 567-572
  • 18 Alm A, Camras CB, Watson PG. Phase III latanoprost studies in Scandinavia, the United Kingdom and the United States. Surv Ophthalmol 1997; 41: S105-S110
  • 19 Alm A, Stjernschantz J. Effects on intraocular pressure and side effects of 0.005 % latanoprost applied once daily, evening or morning. A comparison with timolol. Scandinavian Latanoprost Study Group. Ophthalmology 1995; 102: 1743-1752
  • 20 Brubaker RF. Targeting outflow facility in glaucoma management. Surv Ophthalmol 2003; 48: 17-20
  • 21 Rushton A. Cyclic AMP and intraocular pressure. Lancet 1983; 2: 737
  • 22 Graham SL, Drance SM, Wijsman K et al. Ambulatory blood pressure monitoring in glaucoma: the nocturnal dip. Ophthalmology 1995; 102: 61-69
  • 23 Racz P, Ruzsonyi MR, Nagy ZT et al. Around-the-clock (circadian) intraocular pressure reduction with once-daily application of 0.005 % latanoprost by itself or in combination with timolol. Arch Ophthalmol 1996; 114: 268-273
  • 24 Orzalesi N, Rossetti L, Invernizzi T et al. Effect of timolol, latanoprost, and dorzolamide on circadian IOP in glaucoma or ocular hypertension. Invest Ophthalmol Vis Sci 2000; 41: 2566-2573
  • 25 Netland PA, Landry T, Sullivan EK et al. Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension. Am J Ophthalmol 2001; 132: 472-484
  • 26 Stewart WC, Konstas AG, Nelson LA et al. Meta-analysis of 24-hour intraocular pressure studies evaluating the efficacy of glaucoma medicines. Ophthalmology 2008; 115: 1117-1122
  • 27 Costagliola C, Del Prete A, Verolino M et al. Effect of 0.005 % latanoprost once daily on intraocular pressure in glaucomatous patients not adequately controlled by beta-blockers twice daily: a 3-year follow-up. Experience and incidence of side-effects in a prospective study on 76 patients. Graefes Arch Clin Exp Ophthalmol 2002; 240: 379-386
  • 28 Susanna Jr R, Chew P, Kitazawa Y. Current status of prostaglandin therapy: latanoprost and unoprostone. Surv Ophthalmol 2002; 47: S97-S104
  • 29 Watson P, Stjernschantz J. the Latanoprost Study Group. A six-month, randomized, double-masked study comparing latanoprost with timolol in open-angle glaucoma and ocular hypertension. Ophthalmology 1996; 103: 126-137
  • 30 Sakurai M, Higashide T, Takahashi M et al. Association between genetic polymorphisms of the prostaglandin f2α receptor gene and response to latanoprost. Ophthalmology 2007; 114: 1039-1045
  • 31 Williams RD. Efficacy of bimatoprost in glaucoma and ocular hypertension unresponsive to latanoprost. Adv Ther 2002; 19: 275-281
  • 32 Gandolfi SA, Cimino L. Effect of bimatoprost on patients with primary open-angle glaucoma on ocular hypertension who are nonresponders to latanoprost. Ophthalmology 2003; 110: 609-614
  • 33 Susanna Jr. R, Nicolela MT, Oga E. Additive effect of latanoprost to the combination of timolol and dorzolamide. J Glaucoma 2000; 9: 183-186
  • 34 Diestelhorst M. The additive intraocular pressure-lowering effect of latanoprost 0.005 % daily once and pilocarpine 2 % t.i.d. in patients with open-angle glaucoma or ocular hypertension. A 6-month, randomized, multicenter study. German Latanoprost Study Group. Graefes Arch Clin Exp Ophthalmol 2000; 238: 433-439
  • 35 Stewart WC, Sharpe ED, Day DG et al. Comparison of the efficacy and safety of latanoprost 0.005 % compared to brimonidine 0.2 % or dorzolamide 2 % when added to a topical beta-adrenergic blocker in patients with primary open-angle glaucoma or ocular hypertension. J Ocul Pharmacol Ther 2000; 16: 251-259
  • 36 OʼConnor DJ, Martone JF, Mead A. Additive intraocular pressure lowering effect of various medications with latanoprost. Am J Ophthalmol 2002; 133: 836-837
  • 37 Feldman RM, Tanna AP, Gross RL et al. Comparison of the ocular hypotensive efficacy of adjunctive brimonidine 0.15 % or brinzolamide 1 % in combination with travoprost 0.004 %. Ophthalmology 2007; 114: 1248-1254
  • 38 Tabet R, Stewart WC, Feldman R et al. A review of additivity to prostaglandin analogs: fixed and unfixed combinations. Surv Ophthalmol 2008; 53: S85-S92
  • 39 Kent AR, Vroman DT, Thomas TJ et al. Interaction of pilocarpine with latanoprost in patients with glaucoma and ocular hypertension. J Glaucoma 1999; 8: 257-262
  • 40 McKibbin M, Menage MJ. The effect of once-daily latanoprost on intraocular pressure and pulsatile ocular blood flow in normal tension glaucoma. Eye 1999; 13: 31-34
  • 41 Hung PT, Hsieh JW, Chen YF et al. Efficacy of latanoprost as an adjunct to medical therapy for residual angle-closure glaucoma after iridectomy. J Ocul Pharmacol Ther 2000; 16: 43-47
  • 42 Scherer WJ, Hauber FA. Effect of latanoprost on intraocular pressure in steroid-induced glaucoma. J Glaucoma 2000; 9: 179-182
  • 43 Mastropasqua L, Carpineto P, Ciancaglini M et al. A 12-month, randomized, double-masked study comparing latanoprost with timolol in pigmentary glaucoma. Ophthalmology 1999; 106: 550-555
  • 44 Horsley MB, Chen TC. The use of prostaglandin analogs in the uveitic patient. Semin Ophthalmol 2011; 26: 285-289
  • 45 Alvarado JA, Iguchi R, Martinez J et al. Similar effects of selective laser trabeculoplasty and prostaglandin analogs on the permeability of cultured Schlemm canal cells. Am J Ophthalmol 2010; 150: 254-264
  • 46 Alvarado JA, Iguchi R, Juster R et al. From the bedside to the bench and back again: predicting and improving the outcomes of SLT glaucoma therapy. Trans Am Ophthalmol Soc 2009; 107: 167-181
  • 47 Scherer WJ. Effect of topical prostaglandin analog use on outcome following selective laser trabeculoplasty. J Ocul Pharmacol Ther 2007; 23: 503-512
  • 48 Singh D, Coote MA, OʼHare F et al. Topical prostaglandin analogues do not affect selective laser trabeculoplasty outcomes. Eye 2009; 23: 2194-2199
  • 49 Ayala M, Chen E. The influence of topical prostaglandin analogues in inflammation after selective laser trabeculoplasty treatment. J Ocul Pharmacol Ther 2012; 28: 118-122
  • 50 Ishii K, Tomidokoro A, Nagahara M et al. Effects of topical latanoprost on optic nerve head circulation in rabbits, monkeys, and humans. Invest Ophthalmol Vis Sci 2001; 42: 2957-2963
  • 51 Alm A, Grierson I, Shields MB. Side effects associated with prostaglandin analog therapy. Surv Ophthalmol 2008; 53: S93-S105
  • 52 Honrubia F, García-Sánchez J, Polo V et al. Conjunctival hyperaemia with the use of latanoprost versus other prostaglandin analogues in patients with ocular hypertension or glaucoma: a meta-analysis of randomised clinical trials. Br J Ophthalmol 2009; 93: 316-321
  • 53 Krohn J, Hove VK. Iris cyst associated with topical administration of latanoprost. Am J Ophthalmol 1999; 127: 91-93
  • 54 Wand M, Shields BM. Cystoid macular edema in the era of ocular hypotensive lipids. Am J Ophthalmol 2002; 133: 393-397
  • 55 Arranz-Marquez E, Teus MA. Prostanoids for the management of glaucoma. Expert Opin Drug Saf 2008; 7: 801-808
  • 56 Schumer RA, Camras CB, Mandahl AK. Latanoprost and cystoid macular edema: is there a causal relation?. Curr Opin Ophthalmol 2000; 11: 94-100
  • 57 Wand M, Gilbert CM, Liesegang TJ. Latanoprost and herpes simplex keratitis. Am J Ophthalmol 1999; 127: 602-604
  • 58 Beam G, Reardon G, Zimmerman TJ. Association between ocular herpes simplex virus and topical ocular hypotensive therapy. J Glaucoma 2004; 13: 361-364
  • 59 Tappeiner C, Perren B, Iliev ME et al. Orbitale Fettgewebsatrophie bei lokaler Bimatoprost-Therapie – Kann Bimatoprost einen Enophthalmus verursachen?. Klin Monatsbl Augenheilkd 2008; 225: 443-445
  • 60 Stjernschantz JW, Albert DM, Hu DN et al. Mechanism and clinical significance of prostaglandin-induced iris pigmentation. Surv Ophthalmol 2002; 47: S162-S175
  • 61 Costagliola C, Parmeggiani F, Sebastiani A. Assessing the cost-effectiveness of switching from a beta-blocker to latanoprost in the treatment of ocular hypertension. Expert Opin Pharmacother 2003; 4: 1775-1788
  • 62 Orzalesi N, Rossetti L, Invernizzi T et al. Effect of timolol, latanoprost, and dorzolamide on circadian IOP in glaucoma or ocular hypertension. Invest Ophthalmol Vis Sci 2000; 41: 2566-2573