Planta Med 2012; 78 - PL17
DOI: 10.1055/s-0032-1321351

Neuroprotective effect of compound isolated from Cynanchum paniculatum

BR Yun 1, JB Weon 1, B Lee 1, J Lee 1, CJ Ma 1
  • 1Department of Biomaterials Engineering, Division of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200–701, Korea

Cynanchum paniculatum, belongs to Asclepiadaceae has been used to treat various disease, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time. 4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of Cynanchum paniculatum. 4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells. Furthermore, we found that reactive oxygen specises (ROS) accumulation and Ca2+ concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.