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Planta Med 2012; 78 - PK3
DOI: 10.1055/s-0032-1321319
DOI: 10.1055/s-0032-1321319
Synthetic studies of MA026, A novel antiviral lipocyclodepsipeptide
MA026, a novel lipocyclodepsipeptide, exhibits multiple antiviral activity, and its mode of action is unrevealed. MA026 has the potential to create a novel antiviral drug and thus more biological characterizations are required. To accomplish the biological investigation, a flexible chemical synthesis is essential. MA026 consists of (R)-3-hydroxydecanoic acid, linear peptide and cyclodepsipeptide. To maximize the convergency, MA026 was devided into three segments: branched cyclodepsipeptide 2, tripeptide 3 and fatty acid moiety 4. Macrocyclization of depsipeptide is a key step in the total synthesis, so we chose two macrocyclization sites (A) and (B). Here, we present synthetic studies of MA026.
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