Synthetic studies of MA026, A novel antiviral lipocyclodepsipeptide

MA026, a novel lipocyclodepsipeptide, exhibits multiple antiviral activity, and its mode of action is unrevealed. MA026 has the potential to create a novel antiviral drug and thus more biological characterizations are required. To accomplish the biological investigation, a flexible chemical synthesis is essential. MA026 consists of (R)-3-hydroxydecanoic acid, linear peptide and cyclodepsipeptide. To maximize the convergency, MA026 was devided into three segments: branched cyclodepsipeptide 2, tripeptide 3 and fatty acid moiety 4. Macrocyclization of depsipeptide is a key step in the total synthesis, so we chose two macrocyclization sites (A) and (B). Here, we present synthetic studies of MA026.