Planta Med 2012; 78 - PI363
DOI: 10.1055/s-0032-1321050

Evaluation of the schistosomicidal activity of nor-neolignans from Styrax pohlii

E Soares 1, CS Bertanha 1, PF de Oliveira 1, UO Gonçalves 1, LG Magalhães 1, V Rodrigues 2, MLA Silva 1, DC Tavares 1, AH Januário 1, PM Pauletti 1
  • 1Universidade de Franca, Av. Dr. Armando Salles de Oliveira, 201, 14404–600, Franca, São Paulo, Brazil
  • 2Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, 14049–900, Ribeirão Preto, São Paulo, Brazil

Styrax pohlii A. DC belongs to the family Styracaceae, which is known in Brazil as 'benjoeiro', 'estoraqueiro', 'árvore-de-bálsamo', 'pindaíba', 'pindaubuna' or 'pindauvuna'. This specie is commonly employed in folk medicine to relieve fever. The present study investigated the chemical composition of the bioactive EtOAc fraction of S. pohlii aerial parts, as well as schistosomicidal and cytotoxicity activities. The purification procedure resulted in the isolation of compounds 1-5. The bioassay results indicated that 1, 3, 4 and 5 are able to separate coupled S. mansoni adult worms at 100µM. Although, assayed compounds did not kill the adult schistosomes in vitro. Furthermore, in assayed concentration 1, 3, 4 and 5 were not cytotoxic in the cell line GM07492A (Human lung fibroblast).