Studies on the chemical constituents of Evodia rutaecarpa and Evodia rutaecarpa passed with Liquorice and biological activities

17 indole quinoline alkaloids, 8 limonins, 7 flavonoids, 7 triterpenoids and 11 other compounds were obtained from E. rutaecarpa and E. rutaecarpa passed with Liquorice. 6 of them are new compounds. About 19 compounds were tested by replanting tumor to mice, angioma of zebrafish model for antiangiogenic drug screening and human tumor cells in vitro. Thus compounds evodiagenine (2), evodialimonin (3), rhetsinine (4), dehydroevodiamine (5), wuchuyuamide I (7) and 1-methyl-2-undecyl-4(1H)-quinolone (8) showed moderate activity against human tumor cells, dievodiamine (1) and evodiamine (6) showed good activity. The inhibitory rate of 4 on sarcoma S₁₈₀ was 57.78% at the dose of 5–10mg/kg·d in vivo. Moreover, the inhibition of the active selectivity of cycloxygenase 1 and 4 showed a stronger effect.