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DOI: 10.1055/s-0032-1320872
Desmutagenic and antimutagenic potential of Khaya grandifoliola (C.DC.), meliaceae
Five phenolics were isolated for the first time from the ethanol extract of Khaya grandifoliola leaves. These compounds were identified using spectroscopic analysis (UV, 1H-NMR, 13C-NMR and ESI) as Quercetin 3-O-rhamnoglucoside (rutin), Quercetin 3-O-rhamnoside, Quercetin 3-O-glucoside, Quercetin aglycon and the new 6- methoxycoumarin, 7- arabinofuranoside.
Desmutagenic and antimutagenic activities of specimen extracts of immaculate khaya grandifoliola leaves and flowers were ascertained by measuring the inhibition of Salmonella typhimurium TA 100 His+ revertants induced by ethyl methane sulphonate EMS and ribose lysine RL. A frustration of the induced reversion was observed. The alcoholic extract of both leaves and flowers of khaya grandifoliola exhibited desmutagenic and antimutagenic activity against EMS and RL induced reversion.