Planta Med 2012; 78 - PI184
DOI: 10.1055/s-0032-1320872

Desmutagenic and antimutagenic potential of Khaya grandifoliola (C.DC.), meliaceae

F Hashem 1, ES Aboutabl 2, S El-Souda 3, M Moharam 4, A Mammoun 1
  • 1Pharmacognosy depart., National Research Centre, Tahrir street, Dokki, Cairo, Egypt
  • 2Pharmacognosy depart, Faculty of Pharmacy, Cairo Univeristy, Kasr-El-Aini, Cairo, Egypt
  • 3Chemistry of natural compounds depart., National Research Centre, Tahrir street, Dokki, Cairo, Egypt
  • 4Microbiology depart., National Research Centre, Tahrir street, Dokki, Cairo, Egypt

Five phenolics were isolated for the first time from the ethanol extract of Khaya grandifoliola leaves. These compounds were identified using spectroscopic analysis (UV, 1H-NMR, 13C-NMR and ESI) as Quercetin 3-O-rhamnoglucoside (rutin), Quercetin 3-O-rhamnoside, Quercetin 3-O-glucoside, Quercetin aglycon and the new 6- methoxycoumarin, 7- arabinofuranoside.

Desmutagenic and antimutagenic activities of specimen extracts of immaculate khaya grandifoliola leaves and flowers were ascertained by measuring the inhibition of Salmonella typhimurium TA 100 His+ revertants induced by ethyl methane sulphonate EMS and ribose lysine RL. A frustration of the induced reversion was observed. The alcoholic extract of both leaves and flowers of khaya grandifoliola exhibited desmutagenic and antimutagenic activity against EMS and RL induced reversion.