Planta Med 2012; 78 - CL29
DOI: 10.1055/s-0032-1320264

Marine natural products as modulators of nuclear receptors

MV D'Auria 1, S De Marino 1, V Sepe 1, A Zampella 1, G Bifulco 2, B Renga 3, C D'Amore 3, S Fiorucci 3, C Debitus 4
  • 1Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli “Federico II, 80131 Napoli, Italy
  • 2Dipartimento di Scienze Farmaceutiche, Università di Salerno, 84084 Fisciano (SA), Italy
  • 3Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Nuova Facoltà di Medicina e Chirurgia, 06132 Perugia, Italy
  • 4Institut de Recherche pour le De'veloppement (IRD), Polynesian Research Center on Island Biodiversity, BP529, 98713 Papeete, Tahiti, French Polynesia

Nuclear receptors (NRs) represent one of the most important drug targets in terms of potential therapeutic application, playing a role in every aspect of development, physiology and disease in humans. In recent years many natural products were found to act as ligands for NRs. As consequence of our long standing interest in the chemistry of bioactive marine products, we found that some new natural products were endowed with modulatory activity towards FXR, PXR and PPARγ receptors. The chemistry and the biological activity of these modulators will be discussed.