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Synlett 2013; 24(8): 893-897
DOI: 10.1055/s-0032-1318493
DOI: 10.1055/s-0032-1318493
synpacts
Synthesis of Nucleic Acid Polymers with Non-Canonical Nucleobases
Further Information
Publication History
Received: 25 January 2013
Accepted after revision: 04 March 2013
Publication Date:
19 March 2013 (online)
Abstract
Understanding and controlling the biology of nucleic acids is partially a challenge in synthetic chemistry: How to selectively manipulate a single subunit in a repeating polymer of near-identical units. Herein we examine approaches to tackle this synthetic challenge and highlight a recent contribution from our group that offers an efficient convergent method based on organometallic catalysis.
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References
- 1a Wachowius F, Höbartner C. ChemBioChem 2010; 11: 469
- 1b Fedorova O, Boudvillain M, Kawaoka J, Pyle AM In Handbook of RNA Biochemistry . Wiley-VCH; Weinheim: 2008: 259-293
- 1c Huntzinger E, Possedko M, Winter F, Moine H, Ehresmann C, Romby P In Handbook of RNA Biochemistry . Wiley-VCH; Weinheim: 2008: 151-171
- 2 Tishinov K, Schmidt K, Häussinger D, Gillingham DG. Angew. Chem. Int. Ed. 2012; 51: 12000
- 3 Höbartner C, Wachowius F. Chemical Synthesis of Modified RNA . In The Chemical Biology of Nucleic Acids . John Wiley and Sons; Chichester: 2010: 1-37
- 4 Sasaki S, Onizuka K, Taniguchi Y. Chem. Soc. Rev. 2011; 40: 5698-5706
- 5 Sharp PA. Cell 2009; 136: 577
- 6 Winkler WC, Nahvi A, Roth A, Collins JA, Breaker RR. Nature (London) 2004; 428: 281
- 7 Seto AG, Kingston RE, Lau NC. Mol. Cell 2007; 26: 603
- 8 Bartel DP. Cell 2009; 136: 215
- 9 Nagano T, Fraser P. Cell 2011; 145: 178
- 10a Kawasaki T, Nagatsugi F, Ali MM, Maeda M, Sugiyama K, Hori K, Sasaki S. J. Org. Chem. 2004; 70: 14
- 10b Hattori K, Hirohama T, Imoto S, Kusano S, Nagatsugi F. Chem. Commun. 2009; 6463
- 11 Song C.-X, He C. Acc. Chem. Res. 2011; 44: 709
- 12a Zhou Q, Rokita SE. Proc. Natl. Acad. Sci. U.S.A. 2003; 100: 15452
- 12b Liu Y, Rokita SE. Biochemistry 2012; 51: 1020
- 13 Onizuka K, Taniguchi Y, Sasaki S. Bioconjugate Chem. 2009; 20: 799
- 14a Dalhoff C, Lukinavicius G, Klimasauskas S, Weinhold E. Nat. Chem. Biol. 2006; 2: 31
- 14b Tomkuvienė M, Clouet-d’Orval B, Černiauskas I, Weinhold E, Klimašauskas S. Nucleic Acids Res. 2012; 40: 6765
- 15 Motorin Y, Burhenne J, Teimer R, Koynov K, Willnow S, Weinhold E, Helm M. Nucleic Acids Res. 2011; 39: 1943
- 16 Peacock H, Kannan A, Beal PA, Burrows CJ. J. Org. Chem. 2011; 76: 7295