Synthesis of DS-8108b
18 January 2013 (online)
The reaction scheme contains a few minor mistakes: in B → D one of the solvents is DMM (not DME), compounds I and J are missing ethyl groups, in I → J two equivalents of PhSH are used (not 1.7 equiv) and water is a co-solvent in the second step. The correct scheme is shown below. We apologize for the mistakes.