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Synthesis 2013; 45(4): 459-462
DOI: 10.1055/s-0032-1317983
DOI: 10.1055/s-0032-1317983
paper
One-Pot Two-Step Synthesis of Quinoxalinones and Diazepinones via a Tandem Oxidative Amidation–Deprotection–Cyclization Sequence
Further Information
Publication History
Received: 25 October 2012
Accepted after revision: 12 December 2012
Publication Date:
10 January 2013 (online)
Abstract
This report discloses novel concise syntheses of quinoxalinones and diazepinones via a tandem oxidative amidation–deprotection–cyclization sequence. A selenium dioxide mediated oxidative amidation of arylglyoxals with secondary amines was carried out under microwave irradiation to give the corresponding α-keto amides, followed by an acid-promoted deprotection and cyclization to afford the desired products in moderate to good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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