Manganese(III) Acetate

Dedicated to my honourable mentor Dr. Utpal Bora

Introduction

Manganese(III) acetate [Mn(OAc)₃]-mediated free-radical reactions have emerged as important synthetic methods. Manganese acetate can be used as an oxidizing and chlorinating agent[ ¹ ] and in some cases in alkylations[ ¹ ] and inter- and intramolecular cyclizations.[ ² ] Due to the poor solubility of Mn(OAc)₃ in common organic solvents, Mn(OAc)₃-mediated reactions are often carried out in acetic acid, although other solvents including toluene, alcohols, acetonitrile, dichloromethane and chlorobenzene can be used.[ ³ ] Mn(OAc)₃ promotes the synthesis of many alkaloids,[ ⁴ ] triterpenes,[ ⁵ ] and drugs.[ ⁶ ] Mn(OAc)₃ is commercially available in form of its dehydrate as a brown powder and can be prepared in the laboratory[ ⁷ ] by adding KMnO₄ to a pre-heated mixture of Mn(OAc)₂ and glacial acetic acid (Scheme [1]). Addition of acetic anhydride to the reaction produces the anhydrous form.[ ⁸ ]

Scheme 1 Preparation of manganese (III) acetate

• References

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