PEG 400

Introduction

Polyethylene glycol 400 (PEG 400) is a water-soluble and hygroscopic polymer with a molecular weight of 400 Da.[ ¹ ] At room temperature it exists as colorless viscous liquid. Reactions promoted by PEG 400 have attracted attention due to their ease of workup and inexpensive and eco-friendly nature. It can also act as phase-transfer catalyst.

Till date reactions involving PEG 400 have been carried out and investigated, for example, Heck reaction,[ ² ] Lindlar catalytic hydrogenation,[ ³ ] asymmetric dihydroxylation,[ ⁴ ] Baylis–Hillman reaction,[ ⁵ ] Biginelli reaction,[ ⁶ ] Suzuki–Miyaura coupling,[ ⁷ ] Stille cross-coupling,[ ⁸ ] Wacker reaction,[ ⁹ ] asymmetric aldol reaction,[ ¹⁰ ] 3,4-dihydropyrim­idones via Biginelli reaction,[ ¹¹ ] Strecker reaction,[ ¹² ] etc.

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