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Synlett 2012; 23(17): 2511-2515
DOI: 10.1055/s-0032-1317320
DOI: 10.1055/s-0032-1317320
letter
Pd-Catalyzed Cascade Reaction for the Synthesis of 2-Substituted Indoles
Further Information
Publication History
Received: 22 July 2012
Accepted after revision: 29 August 2012
Publication Date:
28 September 2012 (online)
Abstract
An efficient cascade methodology toward the synthesis of 2-substituted indoles has been developed. The transformation proceeds via a palladium-catalyzed cross-coupling reaction of o-nitrobenzyl cyanides with boronic acids. The use of Fe as co-catalyst during the course of reaction employs significant enhancement in reaction rates. The developed protocol allows for the unprecedented use of arylboronic acids as coupling partners for constructing 2-substituted indoles.
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