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Synlett 2012; 23(17): 2531-2533
DOI: 10.1055/s-0032-1317183
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© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Synthesis of 1,2,3,4-Tetrahydro-5H-2-benzazepin-5-ones

Kazumi Okuro
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada, Fax: +1(613)5625871   Email: howard.alper@uottawa.ca
,
Howard Alper*
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada, Fax: +1(613)5625871   Email: howard.alper@uottawa.ca
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Publication History

Received: 13 June 2012

Accepted after revision: 09 August 2012

Publication Date:
28 September 2012 (online)

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Abstract

Palladium-catalyzed intermolecular cyclocarbonylation of 2-iodobenzylamines with Michael acceptors produces 1,2,3,4-tetrahydro-5H-2-benzazepin-5-one derivatives in moderate to good yields. This methodology enables the direct preparation of highly functionalized 1,2,3,4-tetrahydro-5H-2-benzazepin-5-ones from readily available starting materials.

Key words

cyclocarbonylation - heterocycles - palladium - 1,2,3,4-tetrahydrobenzazepin-5-one - Michael acceptor

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    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
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