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Synlett 2012; 23(15): 2255-2260
DOI: 10.1055/s-0032-1317044
DOI: 10.1055/s-0032-1317044
letter
Novel Synthesis of trans-4,6-Diaryl-5-nitropiperidin-2-ones via Four-Component Reaction from Substituted Nitrostyrenes, Aromatic Aldehydes, Dimethyl Malonate, and Formamide
Further Information
Publication History
Received: 17 June 2012
Accepted after revision: 16 July 2012
Publication Date:
08 August 2012 (online)


Abstract
An effective and practical method has been developed for the diversity-oriented synthesis of trans-4,6-diaryl-5-nitropiperidin-2-ones via four-component reaction from substituted nitrostyrenes, aromatic aldehydes, dimethyl malonate, and formamide for the generation of a wide range of structurally interesting and pharmacologically significant compounds. It is worth mentioning that in the course of this reaction, the formation of products was highly stereoselective.
Key words
multicomponent reaction - combinatorial chemistry - piperidines - Michael addition - piperidin-2-onesSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information