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Synthesis 2012; 44(19): 3085-3089
DOI: 10.1055/s-0032-1317034
DOI: 10.1055/s-0032-1317034
paper
New Efficient Synthesis of 2,3,5-Trisubstituted Pyrimidin-4(3H)-ones from Baylis–Hillman Adducts
Further Information
Publication History
Received: 08 May 2012
Accepted after revision: 16 July 2012
Publication Date:
08 August 2012 (online)
Abstract
Azides obtained from Baylis–Hillman adducts were treated with triphenylphosphine to give the corresponding iminophosphoranes that underwent aza-Wittig reactions with aryl isocyanates and then reacted with amines, alcohol, or phenols in the presence of catalytic amounts of sodium alkoxide or potassium carbonate to give the corresponding 2,3,5-trisubstituted pyrimidin-4(3H)-ones directly in good yields.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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