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Synlett 2012; 23(15): 2274-2278
DOI: 10.1055/s-0032-1317030
DOI: 10.1055/s-0032-1317030
letter
Isocyanide-Based Multicomponent [2+2+1]-Cycloaddition Strategy to Construct Functionalized Spirocyclic Oxindoles
Weitere Informationen
Publikationsverlauf
Received: 16. Juni 2012
Accepted: 12. Juli 2012
Publikationsdatum:
14. August 2012 (online)


Abstract
Isocyanide-based three-component [2+2+1]-cycloaddition reactions from isocyanides, activated alkynes, and isatylidene malononitriles were investigated to provide a new access to spirocyclic oxindole with five-membered carbon rings. The displacement of isatylidene malononitrile with oxindolylideneacetate essentially results in opposite regioselectivity, which adds to its attractiveness.
Key words
isocyanide - activated alkyne - isatylidene malononitrile - spirocyclic oxindole - oxindolylideneacetateSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information