Am J Perinatol 2012; 29(09): 693-698
DOI: 10.1055/s-0032-1314890
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Infants Weighing <1500 g: Better Born Too Small or Too Soon?

Isabella Crippa
1   Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
,
Anna Locatelli
1   Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
,
Sara Consonni
1   Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
,
Alessandro Ghidini
1   Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
,
Patrizia Stoppa
2   Department of Child Neurology and Psychiatry, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
,
Giuseppe Paterlini
3   Department of Neonatology, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
,
Nadia Roncaglia
1   Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Fondazione MBBM, Monza, Italy
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Weitere Informationen

Publikationsverlauf

31. Dezember 2011

14. Februar 2012

Publikationsdatum:
29. Mai 2012 (online)

Abstract

Objective To evaluate the influence of intrauterine growth on intact neurological outcome at 12 to 24 months in a cohort of infants weighing <1500 g at birth.

Study Design This retrospective study was conducted in the Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. Perinatal variables were correlated with occurrence of composite adverse outcome, including neonatal death or adverse neurodevelopmental outcome (ANDO), at 12 to 24 months' follow-up, in 240 consecutive very low-birth-weight (VLBW) neonates prenatally classified as growth restricted (IUGR; n = 100) or appropriate for gestational age (n = 140).

Results Among the 214 surviving neonates, neurological follow-up was available in 163. ANDO was present in 46 children (28%). At multivariate analysis, only gestational age at delivery was independently related to the composite outcome (p < 0.001, odds ratio = 0.69, 95% confidence interval 0.59, 0.81), whereas diagnosis of IUGR was not.

Conclusion Only gestational age at delivery was significantly associated with composite adverse outcome in VLBW preterm infants.

 
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