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Horm Metab Res 2012; 44(04): 273-278
DOI: 10.1055/s-0032-1304581
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

Differential Adipose Tissue Inflammatory State in Obese Nondiabetic Zucker Fatty Rats Compared to Obese Diabetic Zucker Diabetic Fatty Rats

A. Miranville
1   Research and Development, Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt/M, Germany
,
A. W. Herling
1   Research and Development, Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt/M, Germany
,
G. Biemer-Daub
1   Research and Development, Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt/M, Germany
,
M. D. Voss
1   Research and Development, Diabetes Division, Sanofi-Aventis Deutschland GmbH, Frankfurt/M, Germany
› Author Affiliations
Further Information

Publication History

received 01 September 2011

accepted 19 January 2012

Publication Date:
07 March 2012 (online)

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Abstract

Adipose tissue (AT) inflammation is linked to the pathogenesis of diabetes in obesity. Here, we compare the AT inflammatory state of 2 animal models of obesity and obesity plus diabetes, respectively. Obese nondiabetic ZF rats exhibited a trend towards increased proportions of CD11b positive cells in the adipose tissue stroma vascular fraction suggesting a state of increased AT inflammation compared to their lean littermates, but no alterations in systemic inflammatory parameters. In contrast, obese diabetic ZDF rats exhibited systemic as well as local AT inflammation with elevated levels of circulating Regulated upon Activation, Normal T-cell Expressed and Secreted Protein (Rantes), interleukin 1β (IL-1β) and monocyte chemotactic protein 1 (MCP-1), and an increased infiltration of adipose tissue CD11b positive cells. Our data provide a novel phenotypic characterisation of 2 common metabolic animal models and suggest an association of obesity with local inflammation in adipose tissue, and an association of diabetes with local inflammation in adipose tissue plus systemic inflammation. AT inflammation in obesity might therefore initiate a process that above a certain limits finally results in systemic inflammation and diabetes.

Key words

adipose tissue - macrophage phenotype - obesity - inflammation
 

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